Abstract
In a double-blind clinical study, electrocardiogram, blood pressure and systolic time intervals were measured in 40 depressive patients treated with either paroxetine (30 mg/day) or amitriptyline (150 mg/day) for 6 weeks. While amitriptyline significantly increased the heart rate, the QTc interval and the PEP/LVET ratio, paroxetine did not alter any of the cardiovascular parameters measured.
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Battegay R, Hager M, Rauchfleisch U (1985) Double-blind comparative study of paroxetine and amitriptyline in depressed patients of a university psychiatric outpatient clinic (pilot study). Neuropsychobiology 13:31–37
Borup C, Meidahl B, Petersen I-M, Vangtorp A, le Fevre Honore P (1982) An early clinical phase II evaluation of paroxetine, a new potent and selective 5HT-uptake inhibitor in patients with depressive illness. Pharmacopsychiatry 15:183–186
Burckhardt D, Raeder E, Müller V, Imhof P, Neubauer H (1978) Cardiovascular effects of tricyclic and tetracyclic antidepressants. JAMA 239:213–216
Burgess CD, Montgomery S, Wadsworth J, Turner P (1979) Cardiovascular effects of amitriptyline, mianserin, zimelidine and nomifensine in depressed patients. Postgrad Med J 55:704–708
Edwards JG, Goldie A, Papayanni-Papasthatis S (1989) Effect of paroxetine on the electrocardiogram. Psychopharmacology 97:96–98
Feighner JP, Boyer WF (1989) Paroxetine in the treatment of depression: a comparison with imipramine and placebo. Acta Psychiatr Scand [Suppl 350] 80:125–129
Giardina EV, Bigger JT, Glassman AH, Perel JM, Kantor SJ (1979) The electrocardiographic and antiarrhythmic effects of imipramine hydrochloride at therapeutic plasma concentrations. Circulation 60:1045–1052
Goldman LS, Alexander RC, Luchins DJ (1986) Monoamine oxidase inhibitors and tricyclic antidepressants: comparison of their cardiovascular effects. J Clin Psychiatry 47:225–229
Hamilton TC, Norton J, Poyser RH, Thormählen D (1986) Comparison of some effects of paroxetine with amitriptyline on the cardiovascular system in animals. Drug Res 36:460–463
Kuhs H, Rudolf GAE (1989) A double-blind study of the comparative antidepressant effect of paroxetine and amitriptyline. Acta Psychiatr Scand [Suppl 350] 80:145–146
Lewis RP, Rittger PR, Forrester WF, Boudoulas H (1977) A critical review of the systolic time intervals. Circulation 56:146–158
Lund J, Thayssen P, Mengel H, Pedersen OL, Kristensen CB, Gram IF (1982) Paroxetine: pharmacokinetics and cardiovascular effects after oral and intravenous single doses in man. Acta Pharmacol Toxicol 51:351–357
McCelland GR, Raptopoulos P (1985) Cardiovascular effects of paroxetine and amitriptyline after repeated administration to normal volunteers. Br J Clin Pharmacol 20:282
Mertens C, Pintens H (1988) Paroxetine in the treatment of depression. A double-blind multicenter study versus mianserin. Acta Psychiatr Scand 77:683–688
Merwe van der TJ, Silverstone T, Ankier SI, Warrington SJ, Turner P (1984) A double-blind non-crossover placebo-controlled study between group comparison of trazodone and amitriptyline on cardiovascular function in major depressive disorder. Psychopathology [Suppl 2] 17:64–76
Montgomery S (1980) The effect of mianserin on sleep and cardiac function. Curr Med Res Opin [Suppl] 6:23–28
Rickels K, Amsterdam J, Clary C, Fox I, Schweizer E, Weise C (1989) A placebo-controlled, double-blind, clinical trial of paroxetine in depressed outpatients. Acta Psychiatr Scand [Suppl 350] 80:117–123
Roose SP, Glassman AH, Giardina EGV, Walsh BT, Woodring S, Bigger T (1987) Tricyclic antidepressants in depressed patients with cardiac conduction disease. Arch Gen Psychiatry 44:273–275
Roose SP, Glassman AH, Dalack GW (1989) Depression, heart disease, and tricyclic antidepressants. J Clin Psychiatry [Suppl] 50:12–16
Thomas DR, Nelson DR, Johnson AM (1987) Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology 93:193–200
Tyrer P, Marsden CA, Casey P, Seivewright N (1987) Clinical efficacy of paroxetine in resistant depression. J Psychopharmacol 1:251–257
Weissler AM, Harris WS, Schoenfeld CD (1969) Bedside technics for the evaluation of ventricular function. Am J Cardiology 23:577–583
Warrington SJ, Dana-Haeri J, Sinclair AJ (1989) Cardiovascular and psychomotor effects of repeated doses of paroxetine: a comparison with amitriptyline and placebo in healthy men. Acta Psychiatr Scand [Suppl 350] 80:42–44
Yokota S, Ishikura Y, Ono H (1987) Cardiovascular effects of paroxetine, a newly developed antidepressant, in anaesthetised dogs in comparison with those of imipramine, amitriptyline and clomipramine. Jpn J Pharmacol 45:335–342
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Kuhs, H., Rudolf, G.A.E. Cardiovascular effects of paroxetine. Psychopharmacology 102, 379–382 (1990). https://doi.org/10.1007/BF02244107
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DOI: https://doi.org/10.1007/BF02244107