Abstract
The effect of a protein-rich meal on the pharmacokinetics of moclobemide was studied after intravenous (75 mg) and oral (100 mg) administrations of this selective MAO-A inhibitor to eight healthy male volunteers. The meal chosen did not affect plasma concentration-time curves of the drug after oral administration apparently, because the influence of blood flow changes to the liver on hepatic first-pass metabolism (AUC↑) and on systemic clearance (AUC↓) balance each other out.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Melander A, Lalka D, McLean A (1988) Influence of food on the presystemic metabolism of drugs. Pharmacol Ther 38:253–267
Svensson CK, Edwards DJ, Lalka D, Mauriello PM, Middleton EM (1982) Comparison of chromatographic and spectrophotometric analysis of indocyanine green in plasma following administration of multiple doses to man. J Pharm Sci 71:1305–1306
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cole, A.F.D., Baxter, J.G., Jackson, B.J. et al. Pharmacokinetic and metabolic aspects of the moclobemide-food interaction. Psychopharmacology 106 (Suppl 1), S37–S39 (1992). https://doi.org/10.1007/BF02246232
Issue Date:
DOI: https://doi.org/10.1007/BF02246232