Abstract
A technique for intragastric self-administration in rats is presented.
Intravenous self-administration of morphine was compared with intragstric self-administration during 6 consecutive days. There was no difference between the two routes in the total rate of injections.
Medazepam was given for intragastric self-administration at three different doses (2.5, 5.0 and 10.0 mg/kg/injection respectively) and compared with saline. There was an increased response rate at the dose 10 mg/kg/injection.
Medazepam placebo solution (solvent alone) was also compared with medazepam 10 mg/kg/injection. Among the seven experimental rats, six responded higher on medazepam than on the solvent.
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Götestam, K.G. Intragastric self-administration of medazepam in rats. Psychopharmacologia 28, 87–94 (1973). https://doi.org/10.1007/BF00413960
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DOI: https://doi.org/10.1007/BF00413960