Abstract
Two experiments on the effects of fenfluramine on FR responding are reported. In Experiment 1 two rats were trained on an FR 10 schedule of reinforcement. After more than 30 h training, intraperitoneal injection of saline, 2, 4 and 8 mg/kg fenfluramine were given. Disruption of the initial stages of responding was noted after 2 and 4 mg/kg, with complete disruption of responding in 1 animal after 8 mg/kg administration. In Experiment 2, 2 rats trained on an FR 30 schedule of reinforcement received chronic 15 days administration of 4 mg/kg fenfluramine. Disruption of responding was noted after the first administration. The degree of disruption lessened by the fifteenth day of administration.
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Taylor, M. The effects of fenfluramine on fixed ratio responding. Psychopharmacologia 32, 351–358 (1973). https://doi.org/10.1007/BF00429471
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DOI: https://doi.org/10.1007/BF00429471