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Chronic anorexic and behavioural effects of the fenfluramine derivative SE 780 in rats

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Abstract

The behavioural and anorexic effects of the fenfluramine derivative “SE 780” in rats were studied after chronic administration over 35 days. Behavioural effects of the compound were assessed by “time sampling” behavioural categorisation, on days 1, 14 and 28 of administration. An initial sedative effect observed after acute administration was absent on days 14 and 28 of observation, when the drug had no behavioural effects at all. The anorexic properties of the drug were investigated in two ways. Firstly, by measuring daily body weights; and secondly by measuring intake of food over a 2 h period on observation days. The drug appeared to be a highly potent anorexiant in that tolerance to its effects built up very slowly. It is suggested that SE 780 may be an anorexic agent which is superior to Fenfluramine in two ways; firstly, it lacks stimulant properties after chronic administration, and secondly it is active over longer periods of time; as such it merits further study in humans.

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References

  • Goudie, A. J., Taylor, M.: Time sampling of rat exploratory behaviour: A reliable screening test for the C. N. S. effects of anorexic agents. Psychopharmacologia (Berl.) 35, 1–12 (1974)

    Google Scholar 

  • Pankseep, J., Booth, D. A.: Tolerance in the depression of intake when amphetamine is added to the rat's food. Psychopharmacologia (Berl.) 29, 45–54 (1973)

    Google Scholar 

  • Pawan, G. L. S.: Paper submitted to the international symposium on fenfluramine. Nassau 1971 a

  • Pawan, G. L. S.: Preliminary study of the effects of the fenfluramine derivative “S 992” in man. Brit. J. Pharmacol. 41, 416–417p (1971b)

    Google Scholar 

  • Taylor, M., Goudie, A. J., Williams, A.: Chronic effects of fenfluramine on behaviour and body weight in rats. Psychopharmacologia (Berl.) 31, 63–76 (1973)

    Google Scholar 

  • Taylor, M., Livesey, J., Dempster, T., Bunce, R.: The effects of acutely administered fenfluramine on activity and eating behaviour. Psychopharmacologia (Berl.) 21, 165–173 (1971)

    Google Scholar 

  • Weischer, M. L., Opitz, K.: Effect of fenfluramine, chlorphentermine and related compounds on the behaviour of aggressive mice. Arch. int. Pharmacodyn. 195, 252–259 (1972)

    Google Scholar 

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Authors and Affiliations

  1. Department of Psychology, University College of North Wales, Bangor, Caernarvonshire, North Wales

    M. Taylor & A. J. Goudie

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  1. M. Taylor
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  2. A. J. Goudie
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This compound has also been referred to as “S 992”.

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Taylor, M., Goudie, A.J. Chronic anorexic and behavioural effects of the fenfluramine derivative SE 780 in rats. Psychopharmacologia 35, 13–17 (1974). https://doi.org/10.1007/BF00421561

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  • DOI: https://doi.org/10.1007/BF00421561

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