Skip to main content
SpringerLink
Log in

Differential antagonism by naloxone of inhibitory effects of haloperidol and morphine on brain self-stimulation

  • Published:
Psychopharmacologia Aims and scope Submit manuscript

Abstract

Haloperidol (0.16 mg/kg) or morphine sulfate (40 mg/kg), injected subcutaneously, completely suppressed bar-pressing for brain self-stimulation in rats implanted with electrodes in the lateral hypothalamus. Haloperidol also caused catalepsy and ptosis while morphine produced catatonia with exophthalmia. Naloxone in a dose (5 mg/kg) which was ineffective when given alone, differentially reversed the morphine-effects but was without any reversing influence on the actions of haloperidol.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ayhan, I. H., Randrup, A.: Inhibitory effects of amphetamine, L-Dopa apomorphine on morphine-induced behavioural excitation of rats. Arch. int. Pharmacodyn. 204, 283–292 (1973)

    Google Scholar 

  • Dickerman, S., Clark, J., Dickerman, E., Meites, J.: Effect of haloperidol on serum and pituitary prolactin and on hypothalamic PIF in rats. Neuroendocrinol. 9, 332–340 (1972)

    Google Scholar 

  • Dobrin, E. I., Mares, S. E.: Effects of morphine on serum gonadotrophin levels in rats and monkeys. Drug Addiction, Vol. 4, J. Singh and H. Lal, Eds. New York: International Book Corp. 1974

    Google Scholar 

  • Geivers, H., Xhonneux, R., Wauquier, A., Van Nueten, J., Reneman, R.: Programmable stimulator for biomedical research. 4th Annual Meeting, Biomedical Engineering Society, paper 3.12 (1973)

  • Janssen, P. A. J., Niemegeers, C. J. E., Schellekens, K. H. L.: Is it possible to predict the clinical effects of neuroleptic drugs (Major Tranquillizers) from animal data? Part I. “Neuroleptic activity spectra” for rats. Arzneimittel-Forsch. 15, 104–117 (1965)

    Google Scholar 

  • Lal, H., Puri, S. K.: Effect of acute morphine or haloperidol administration on catalepsy and striatal dopamine turnover in rat chronically treated with morphine or haloperidol. Pharmacologist 15, 259 (1973)

    Google Scholar 

  • Maggiolo, C., Huidobro, F.: Administration of pellets of morphine to mice: abstinence syndrome. Acta physiol. lat.-amer. 11, 70–78 (1961)

    Google Scholar 

  • Puri, S. K., Lal, H.: Effect of morphine, haloperidol, apomorphine and benztropine on dopamine turnover in the rat corpus striatum. Evidence showing morphine-induced reduction in CNS dopaminergic activity. Fed. Proc. 32, 758 (1973)

    Google Scholar 

  • Puri, S. K., Lal, H.: Tolerance to the behavioral and neurochemical effects of haloperidol and morphine in rats chronically treated with morphine or haloperidol. Naunyn-Schmiedeberg's Arch. Pharmacol. 282, 155–170 (1974)

    Google Scholar 

  • Puri, S. K., Reddy, C. R., Lal, H.: Blockade of central dopaminergic receptors by morphine: effect of haloperidol, apomorphine or benztropine. Res. Comm. Chem. Path. Pharmacol. 5, 389–401 (1973)

    Google Scholar 

  • Saelens, J. K., Granat, F. R., Sawayer, W. K.: The mouse jumping test. A simple screening method to estimate the physical dependence catalepsy of analgesics. Arch. int. Pharmacodyn. 190, 213–218 (1971)

    Google Scholar 

  • Vanderwende, C., Spoerlein, M. T.: Role of dopaminergic receptors in morphine analgesia and tolerance. Res. Commun. Chem. Path. Pharmacol. 5, 35 (1973)

    Google Scholar 

  • Wauquier, A., Niemegeers, C. J. E., Geivers, H. A.: Intracranial self-stimulation in rats as a function of various stimulus parameters. I. An empirical study with monopolar electrodes in the medial forebrain bundle. Psychopharmacologia (Berl.) 23, 238–260 (1972)

    Google Scholar 

  • Wauquier, A., Niemegeers, C. J. E.: Intracranial self-stimulation in rats as a function of various stimulus parameters. II. Influence of haloperidol, pimozide, and pipamperone on medial forebrain bundle stimulation with monopolar electrodes. Psychopharmacologia (Berl.) 27, 191–202 (1972)

    Google Scholar 

  • Wauquier, A., Niemegeers, C. J. E.: Intracranial self-stimulation in rats as a function of various stimulus parameters. III. Influence of apomorphine on medial forebrain bundle stimulation with monopolar electrodes. Psychopharmacologia (Berl.) 30, 163–172 (1973)

    Google Scholar 

  • Wauquier, A., Niemegeers, C. J. E.: Intracranial self-stimulation in rats as a function of various stimulus parameters. IV. Influence of amphetamine on medial forebrain bundle stimulation with monopolar electrodes. Psychopharmacologia (Berl.) 34, 265–274 (1974)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemical Pharmacology, Janssen Pharmaceutica, Research Laboratoria, Beerse, Belgium

    Albert Wauquier, Carlos J. E. Niemegeers & Harbans Lal

Authors
  1. Albert Wauquier
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carlos J. E. Niemegeers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Harbans Lal
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Visiting pharmacologist from Department of Pharmacology and Psychology, University of Rhode Island, Kingston, R. I., U.S.A.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wauquier, A., Niemegeers, C.J.E. & Lal, H. Differential antagonism by naloxone of inhibitory effects of haloperidol and morphine on brain self-stimulation. Psychopharmacologia 37, 303–310 (1974). https://doi.org/10.1007/BF00428916

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00428916

Key words

Search

Navigation