Abstract
SKF 525 A was found possess sedative properties in rats at doses of 25 and 50 mg per kg, when injected intraperitoneally. The behavioural effects of the drug were assessed in two ways. Firstly, by “Time Sampling Behavioural Categorisation” of exploratory behaviour; and secondly by activity measurements obtained with an ultrasonic motion recorder. The results clearly demonstrate that SKF 525A has sedative properties in rats at doses which are conventionally used to inhibit metabolism of a wide range of drugs. The implications of these results for the use of SKF 525 A in the study of the actions of psychotropic drugs are discussed.
Similar content being viewed by others
References
Anders, M. W.: Enhancement and inhibition of drug metabolism. Ann. Rev. Pharmacol. 11, 37–56 (1971)
Axelrod, J., Reichenthal, J., Brodie, B. B.: Mechanism of the potentiating action of Β-diethylaminoethyl diphenylpropylacetate. J. Pharmacol. exp. Ther. 112, 49–54 (1954)
Benakis, A., Thomasset, R.: Metabolism of amphetamines and their interactions with barbiturates and SKF 525 A. In: Amphetamines and related compounds, E. Costa, and S. Garratini, eds. New York: Raven Press 1970
Cho, A. K., Lindeke, B., Sum, C. Y.: The N-hydroxylation of phentermine (2-methyl-2-amino-1-phenylpropane). Properties of the enzyme system. Drug Metab. Disp., 2, 1–7 (1974)
Cook, L., Toner, J. J., Fellows, E. J.: The effect of Β-diethylaminoethyldiphenylpropylacetate hydrochloride (SKF No. 525 A) on hexobarbital. J. Pharmacol. exp. Ther. 111, 131–141 (1954)
Dews, P. B.: Studies on behaviour, IV. Stimulant actions of methamphetamine. J. Pharmacol. exp. Ther. 122, 127–147 (1958)
Glick, S. D., Milloy, S.: Rate dependent effects of d-amphetamine on locomotor activity in mice: Possible relation to minimal brain dysfunction. Europ. J. Pharmacol. 24, 266–288 (1973)
Goldberg, M. E., Sledge, K., Dubinsky, B., Robichaud, R. C.: The influence of SKF 525 A on the acute pharmacological properties of chlordiazepoxide. Arch. int. Pharmacodyn. 204, 12–19 (1973)
Goudie, A. J., Taylor, M.: Time sampling of rat exploratory behaviour: A reliable screening test for the C.N.S. effects of anorexic agents. Psychopharmacologia (Berl.) 35, 1–12 (1974)
Goudie, A. J., Taylor, M., Wheeler, T. J.: Chronic anorexic and behavioural effects of the fenfluramine metabolite, norfenfluramine: An evaluation of its role in the actions of fenfluramine. Psychopharmacologia (Berl.) 38, 67–74 (1974)
Mantilla-Plata, B., Harbison, R. D.: Effects of phenobarbital and SKF 525 A pretreatment, sex, liver injury and vehicle on δ9-tetrahydrocannabinol toxicity. Toxicol. appl. Pharmacol. 27, 123–130 (1974)
Mechoulam, R.: Marihuana chemistry. Science 168, 1159–1166 (1970)
Shah, N. S., Gibson, B. R.: Prolongation of the disappearance of mescaline-14C by SKF 525 A. Res. Comm. Chem. Path. Pharmacol. 6, 779–782 (1973)
Sofia, R. D.: The lethal effects of δ9-tetrahydrocannabinol in mice enhanced by pretreatment with SKF 525 A or chloramphenicol. Europ. J. Pharmacol. 26, 383–385 (1974)
Sofia, R. D., Barry, H.: Depressant effect of δ1-tetrahydrocannabinol enhanced by inhibition of its metabolism. Europ. J. Pharmacol. 13, 134–137 (1970)
Taylor, M., Goudie, A. J., Williams, A.: The effects of chronic fenfluramine administration on behaviour and body weight. Psychopharmacologia (Berl.) 31, 63–76 (1973)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goudie, A.J., Kelley, M., Taylor, M. et al. Acute sedative properties of SKF 525 A in rats: Implications for its use as a metabolism inhibitor in the study of psychoactive drugs. Psychopharmacologia 41, 291–294 (1975). https://doi.org/10.1007/BF00428939
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00428939