Abstract
Aggression, which is normally seen during withdrawal from narcotics, could not be produced in morphine-dependent rats by the administration of naloxone at doses which cause other signs of withdrawal. Apomorphine injected instead of naloxone was capable of producing aggression, without other withdrawal signs. Naturally occurring aggression (72-hr withdrawal) was enhanced by apomorphine and unaffected by naloxone.
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Andén, N. E., Robenson, A., Fuxe, K., Hokfelt, T.: Evidence for dopamine receptor stimulation by apomorphine. J. Pharm. Pharmacol. 19, 627–629 (1967)
Blumberg, H., Dayton, H.: Naloxone and related compounds. In: Agonist and antagonist actions of narcotic and analgesic drugs, H. Kosterlitz, H. Collier, and J. Villareal, eds., pp. 110–119. Baltimore: University Press 1973
Boshka, S. C., Weisman, M. C., Thor, D. H.: A technique for inducing aggression in rats utilizing morphine withdrawal. Psychol. Rec. 16, 541–543 (1966)
Cheney, D. L., Goldstein, A.: Tolerance to opioid narcotics: time course and reversibility of physical dependence in mice. Nature (Lond.) 232, 477–478 (1971)
Drawbaugh, R. B., Lal, H.: Reversal by narcotic antagonist of a narcotic action elicited by a conditional stimulus. Nature (Lond.) 247, 65–67 (1974)
Gianutsos, G., Drawbaugh, R. B., Hynes, M. D., Lal, H.: The narcotic withdrawal syndrome in the rat. In: Methods in narcotic research, S. Ehrenpreis and E. A. Neidel, eds., pp. 293–309. New York: Marcel Dekker 1975
Gianutsos, G., Hynes, M. D., Puri, S. K., Drawbaugh, R. B., Lal, H.: Effect of apomorphine and nigrostriatal lesions on aggression and striatal dopamine turnover during morphine withdrawal: evidence for dopaminergic supersensitivity in protracted abstinence. Psychopharmacologia (Berl.) 34, 37–44 (1974)
Hynes, M. D., Gianutsos, G., Lal, H.: Effects of pilocarpine and atropine on the morphine withdrawal syndrome. Committee of Problems of Drug Dependence (in preparation)
Iwamoto, E. T., Ho, I. K., Way, E. L.: Elevation of brain dopamine during naloxone-precipitated withdrawal in morphine dependent mice and rats. J. Pharmacol. exp. Ther. 187, 558–567 (1973)
Lal, H., O'Brien, J., Puri, S. K.: Morphine-withdrawal aggression: sensitization by amphetamines. Psychopharmacologia (Berl.) 22, 217–223 (1971)
Lal, H., Puri, S. K.: Morphine-withdrawal aggression: role of dopaminergic stimulation. In: Drug addiction, vol.1, J. Singh, L. Miller, and H. Lal, eds., pp. 301–310. Mount Kisco, N. Y.: Futura Press 1972
Marshall, I., Smith, D. B.: Acute and chronic morphine treatment and the hydroxylation of [1-14C]-l-tyrosine in the mouse brain. Brit. J. Pharmacol. 50, 428–430 (1974)
Martin, W. R., Wikler, A., Eades, C. G., Pescor, F. T.: Tolerance to and physical dependence on morphine in rats. Psychopharmacologia (Berl.) 4, 247–260 (1963)
Puri, S. K., Lal, H.: Effect of dopaminergic stimulation or blockade on morphine-withdrawal aggression. Psychopharmacologia (Berl.) 32, 113–118 (1973)
Thor, D. H., Hoats, D. L., Thor, C. J.: Morphine induced fighting and prior social experience. Psychon. Sci. 18, 137–139 (1970)
Van Nueten, J. M., Lal, H.: Naloxone-induced facilitation of contractions, spontaneous activity and tolerance to morphine in ileum of morphine dependent guinea pig. Arch. int. Pharmacodyn. 208, 378–383 (1974)
Wei, E., Loh, H. H., Way, E. L.: Quantitative aspects of precipitated abstinence in morphine-dependent rats. J. Pharmacol. exp. Ther. 185, 108–115 (1973)
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Gianutsos, G., Hynes, M.D., Drawbaugh, R.B. et al. Paradoxical absence of aggression during naloxone-precipitated morphine withdrawal. Psychopharmacologia 43, 43–46 (1975). https://doi.org/10.1007/BF00437613
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DOI: https://doi.org/10.1007/BF00437613