Abstract
Tandamine hydrochloride, a thiopyranoindole, was more active than desmethylimipramine in inhibiting the tyramine pressor response after single oral doses in human volunteers. When compared with a placebo, tandamine was found to possess significant anticholinergic activity, to reduce appetite and to produce sedation. Compared with clomipramine, it caused a smaller inhibition of 5-HT but a more marked inhibition of dopamine uptake into human platelets. Further clinical and pharmacological studies with tandamine may help to elucidate the respective roles of different monoamines in depression, sedation and appetite.
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References
Blundell, J. E., Leshem, M. B.: The effect of 5-hydroxytryptophan on food intake and on the anorexic action of amphetamine and fenfluramine. J. Pharm. Pharmacol. 27, 31–37 (1975)
Freyschuss, U., Sjöqvist, F., Tuck, D.: Tyramine pressor effects in man before and during treatment with notriptyline or E.C.T. Pharmacol. Clin. 2, 72–78 (1970)
Ghose, K., Turner, P., Coppen, A.: Intravenous tyramine pressor response in depression. Lancet 1975 I, 1317–1318
Ghose, K., Gifford, L. A., Turner, P., Leighton, M.: Studies of the interaction of desmethylimipramine with tyramine in man after a single oral dose, and its correlation with plasma concentration. Brit. J. clin. Pharmacol. 3, 334–336 (1976)
Gifford, L. A., Turner, P., Pare, C. M. B.: Sensitive method for the routine determination of tricyclic antidepressants in plasma using a specific nitrogen detector. J. Chromatogr. 105, 107–113 (1975)
Gifford, L. A., Witts, D. J.: Sensitive method for the determination of tandamine hydrochloride in plasma using a specific nitrogen detector. Brit. J. clin. Pharmacol. 3, 337–339 (1976)
Kingsley, P. J., Turner, P.: Class experiment in clinical pharmacology with benzilonium bromide, an anticholinergic drug. Europ. J. clin. Pharmacol. 7, 141–143 (1974)
Lippmann, W., Pugsley, T. A.: The effects of tandamine, a new potential antidepressant agent, on biogenic amine uptake mechanisms and related activities. Biochem. Pharmacol. 25, 1179–1186 (1976)
Pugsley, T., Lippmann, W.: Effects of tandamine and pirandamine, a new potential antidepressant on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities. Psychopharmacology 47, 33–41 (1976)
Sneddon, J. M., Turner, P.: The effect of local guanethidine on the palpebral fissure and the pupil in thyrotoxicosis, and its interaction with sympathomimetic amines. J. Physiol. (Lond.) 189, 20–22 (1967)
Trenchard, A., Turner, P., Pare, C. M. B., Hills, M.: The effects of protriptyline and clomipramine in vitro on the uptake of 5-hydroxytryptamine and dopamine in human platelet-rich plasma. Psychopharmacologia (Berl.) 43, 89–93 (1975)
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Ehsanullah, R.S.B., Ghose, K., Kirby, M.J. et al. Clinical pharmacological studies of tandamine, a potential antidepressive drug. Psychopharmacology 52, 73–77 (1977). https://doi.org/10.1007/BF00426603
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DOI: https://doi.org/10.1007/BF00426603