Abstract
Food reward has been associated with activation of noradrenergic mechanisms in the brain. Using rats trained to press a lever for food reward, we have investigated the effects of 6-hydroxydopamine lesions, which severly depleted hypothalamic noradrenaline, on the willingness of the rats to press the lever for food reward. We found that performance in the food-rewarded task was significantly impaired following such lesions, and that this was especially marked when the task was made more difficult. Form our results we suggest that ventral noradrenaline bundle lesions can decrease the rewarding nature of food, thus making the animals less willing to work for food reward.
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References
Ahlskog, J. E.: Food intake and amphetamine anorexia after selective forebrain norepinephrine loss. Brain Res. 82, 211–240 (1974)
Ahlskog, J. E., Hoebel, B. G.: Overeating and obesity from damage to a noradrenergic system in the brain. Science 182, 166–169 (1973)
Anden, N. E., Jukes, M. G. M., Lundberg, A., Vyklicky, L.: The effect of DOPA on the spinal cord. Acta Physiol. Scand. 67, 373–386 (1966)
Berger, B. D., Wise, C. D., Stein, L.: Norepinephrine: Reversal of anorexia in rats with lateral hypothalamic damage. Science 172, 281–284 (1971)
Bolme, P., Fuxe, K., Lidbrink, P.: On the function of central catecholamine neurons — their role in cardiovascular and and arousal mechanisms. Res. Commun. Chem. Pathol. Pharmacol. 4, 657–696 (1972)
Broekkamp, C. L. E., Honig, W. M. G., Pauli, A. I., Van Rossum, J. M.: Pharmacological suppression of eating behaviour in relation to diencephalic noradrenergic receptors. Life Sci. 14, 473–481 (1974)
Chang, C. C.: A sensitive method for spectrophotofluorimetric assay of catecholamines. Int. J. Neuropharmacol. 3, 643–649 (1964)
Euler, U. S. von, Lishajko, F.: Improved technique for the fluorimetric estimation of catecholamines. Acta Physiol. Scand. 51, 348–356 (1961)
Grossman, S. P.: Eating or drinking elicited by direct adrenergic or cholinergic stimulation of the hypothalamus. Science 132, 301–302 (1960)
Herberg, L. J., Franklin, K. B. J.: Adrenergic feeding: Its blockade or reversal by posterior VMH lesions, and a new hypothesis. Physiol. Behav. 8, 1029–1034 (1972)
Hoebel, B. G.: Satiety: Hypothalamic stimulation, anorectic drugs and neurochemical substrates. In: Hunger—basic mechanisms and clinical implications, Noven, Wyrwicka, Bray, eds., New York: Raven Press 1976
Kelly, P. H., Rolls, E T., Shaw, S. G.: Functions of catecholamines in brain-stimulation reward. Brain Res. 66, 363–364 (1974)
Konig, J. F. R., Klippel, R. A.: The rat brain. A stereotaxic atlas of the forebrain and lower parts of the brainstem. Baltimore: Williams and Wilkins 1963
Leibowitz, S. F.: Brain catecholaminergic mechanisms for control of hunger. In: Hunger—basic mechanisms and clinical implications, Novin, Wyrwicka, Bray, eds. New York: Raven Press 1976
Mason, S. T., Fibiger, H. C.: Altered exploratory behaviour after 6-OHDA lesion to the dorsal noradrenergic bundle. Nature 269, 704–705 (1977)
Mason, S. T., Iversen, S. D.: Learning in the absence of forebrain noradrenaline. Nature 258, 422–424 (1975)
Smith, G. P., Gibbs, J.: Cholecystokinin and satiety: Theoretic and therapeutic implications. In: Hunger—basic mechanisms and clinical implications, Novin, Wyrwicka, Bray, eds. New York: Raven Press 1976
Ungerstedt, U.: Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol. Scand. [Suppl] 367, 1–48 (1971)
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Kruk, Z.L., Millar, J. The effect of bilateral ventral noradrenaline bundle lesions on lever pressing for food in rats. Psychopharmacology 64, 41–43 (1979). https://doi.org/10.1007/BF00427343
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DOI: https://doi.org/10.1007/BF00427343