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3H-imipramine high-affinity binding sites in rat brain. Effects of imipramine and lithium

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Abstract

The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five weeks of lithium treatment decreased the number of binding sites, but had no effect on the affinity constants. Long-term imipramine treatment had no effect on the number of binding sites but apparently decreased the affinity. The latter effect was probably due to imipramine remaining in the membrane preparation.

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References

  • Langer SZ, Briley M (1981) High-affinity 3H-imipramine binding: a new biological tool for studies in depression. Trends in Neuro Sciences 4:28–31

    Google Scholar 

  • Paul SM, Rehavi M, Skolnick P, Goodwin FK (1980) Demonstration of specific “High affinity” binding sites for [3H]imipramine on human platelets. Life Sci 26:953–959

    Google Scholar 

  • Pestronk A, Drachman DB (1980) Lithium reduces the number of acetylcholine receptors in skeletal muscle. Science 210:342–343

    Google Scholar 

  • Peterson GL (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83:346

    Google Scholar 

  • Raisman R, Briley MS, Langer SZ (1980) Specific tricyclic antidepressant binding sites in rat brain characterised by high-affinity 3H-imipramine binding. Eur J Pharmacol 61:373–380

    Google Scholar 

  • Rehavi M, Paul SM, Skolnick P, Goodwin FK (1980) Demonstration of specific high affinity binding sites for [3H] imipramine in human brain. Life Sci 26:2273–2279

    Google Scholar 

  • Rosenblatt JE, Pert A, Layton B, Bunney WE (1980) Chronic lithium reduces [3H]spiroperidol binding in rat striatum. Eur J Pharmacol 67:321–322

    Google Scholar 

  • Sette M, Raisman R, Briley M, Langer SZ (1981) Localisation of tricyclic antidepressant binding sites on serotonin nerve terminals. J Neurochem 37:40–42

    Google Scholar 

  • Talvenheimo J, Nelson PJ, Rudnick G (1979) Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport. J Biol Chem 254:4631–4635

    Google Scholar 

  • Treiser S, Kellar KJ (1980) Lithium effects on serotonin receptors in rat brain. Eur J Pharmacol 64:183–185

    Google Scholar 

  • Verimer T, Goodale DB, Long JP, Flynn JR (1980) Lithium effects on haloperidol-induced pre- and postsynaptic dopamine receptor supersensitivity. Common J Pharm Pharmacol 32:665

    Google Scholar 

Download references

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Authors and Affiliations

  1. Psychochemistry Institute, University of Copenhagen, Rigshospitalet, 9, Blegdamsvej, DK-2100, Copenhagen Ø, Denmark

    Per Plenge & E. T. Mellerup

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  1. Per Plenge
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  2. E. T. Mellerup
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Plenge, P., Mellerup, E.T. 3H-imipramine high-affinity binding sites in rat brain. Effects of imipramine and lithium. Psychopharmacology 77, 94–97 (1982). https://doi.org/10.1007/BF00436105

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  • DOI: https://doi.org/10.1007/BF00436105

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