Abstract
In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-308 (20 mg) exerted a strong sedative effect as judged by self-reported coordination scores and performance on logical reasoning and reaction time tests. The effect was evident almost immediately and, on the coordination and reasoning tests, lasted up to 8 h following ingestion. Attention is drawn to the need to extend performance testing in order to maximise test sensitivity. No drug had any consistent or strong influence on cardiovascular measures.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Baddeley AD (1968) A 3 min reasoning test based on grammatical transformation. Psychonom Sci 10:341–342
Barone D, Corsico N, Diena A, Restrelli A, Roslenghi F, Glasser A (1982) Biochemical and pharmacological activities of zetidoline (DL 308-IT): a new antidopaminergic agent. J Pharm Pharmacol 34:129–132
Carter RC, Kennedy RS, Bittner AC (1981) Grammatical reasoning: a stable performance yardstick. Hum Factors 23:587–591
Folkard S, Knauth P, Monk TH, Rutenfranz J (1976) The effect of memory load on the circadian variation in performance efficiency under a rapidly rotating shift system. Ergonomics 19:479–488
Fontanella L, Corsico N, Diena A, Galliani G, Glasser A (1981) Synthesis of new psychotropic 2-imidazolidinones. Il Farmaco Ed Sci 36:3–12
Herbert M, Johns MW, Dore C (1976) Factor analysis of analogue scales measuring subjective feelings before and after sleep. Br J Med Psychol 49:373–379
Herbert M, Bourke JB, Rose JM (1979) The assessment of preoperative medication by a visual analogue technique. In: Oborne DJ, Eiser JR (eds) Research in psychology and medicine, vol 1. Academic Press, London
Hindmarch I (1980) Psychomotor function and psychoactive drugs. Br J Clin Pharmacol 10:189–209
Nicholson AN (1979) Performance studies with diazepam and its hydroxylated metabolites. Br J Clin Pharmacol 8: suppl 1, 395–425
Szabadi E, Bradshaw CM, Gaszner P (1980) The comparison of the effects of DL-308, a potentially new neuroleptic agent, and thioridazine on some psychological and physiological functions in healthy volunteers. Psychopharmacology 68:125–134
Wilkinson RT, Houghton D (1975) Portable four-choice reaction time test with magnetic tape memory. Behav Res Method Instr 7:441–446
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Herbert, M., Standen, P.J., Short, A.H. et al. A comparison of some psychological and physiological effects exerted by zetidoline (DL308) and by oxazepam. Psychopharmacology 81, 335–339 (1983). https://doi.org/10.1007/BF00427573
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00427573