Abstract
The effect of 6-OHDA-induced lesions of neostriatum on locomotor activity, stereotypy and anorexia induced by amphetamine (0.5 mg/kg, 1.5 mg/kg and 5.0 mg/kg IP) was examined. Lesioned rats demonstrated attenuated stereotypy and anorexia but enhanced locomotor activity to amphetamine. Biochemical analysis of dopamine and noradrenaline in specific forebrain areas demonstrated significant dopamine depletion in neostriatum. Dopamine levels in mesolimbic, frontal cortex and hypothalamic areas, and noradrenaline in frontal cortex and hypothalamic areas, were not significantly reduced. The data were interpreted in terms of a response incompatibility hypothesis. It is proposed that stereotyped responses mediated by nigrostriatal dopamine neurones are incompatible with eating. In addition, it is suggested that a second form of competition, at the neuro-anatomical level, occurs between mesolimbic and nigrostriatal systems for motor output pathways and the ultimate expression of behaviour. The role of noradrenaline in amphetamine anorexia is also discussed.
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References
Ahlskog SE (1974) Food intake and amphetamine anorexia after selective forebrain norepinephrine loss. Brain Res 82:211–240
Breese GR, Traylor TD (1970) Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: Evidence for selective degeneration of catecholamine neurones. J Pharmacol Exp Ther 174:413–420
Breese GR, Traylor TD (1971) Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine. Br J Pharmacol 42:88–99
Burridge SL, Blundell JE (1979) Amphetamine anorexia: antagonism by typical but not atypical neuroleptics. Neuropharmacology 18:453–457
Carey RJ (1976) Effects of selective forebrain depletions of norepinephrine and serotonin on the activity and food intake effects of amphetamine and fenfluramine. Pharmacol Biochem Behav 5:519–523
Carey RJ, Goodall EB (1975) Attenuation of amphetamine anorexia by unilateral nigra striatal lesions. Neuropharmacology 14:827–834
Carlton PL (1963) Cholinergic mechanisms in the control of behaviour by the brain. Psychol Rev 79:19–39
Cole SO (1972) The relationship of amphetamine-induced anorexia and freezing under free-feeding conditions. Pharmacol Res Commun 4:71–76
Creese I, Iversen SD (1974) A role of forebrain dopamine systems in amphetamine induced stereotyped behaviour in the rat. Psychopharmacology 39:345–357
Cuello AC, Hiley CR, Iversen LL (1973) Use of catechol-o-methyl transferase for the enzyme radiochemical assay of dopamine. J Neurochem 21:1337–1340
Emson PC, Koob GF (1978) The origin and distribution of dopamine containing afferents to the rat frontal cortex. Brain Res 142:249–267
Heffner TG, Zigmond MJ, Stricker EM (1977) Effects of dopaminergic agnonists and antagonists on feeding in intact and 6-hydroxydopamine treated rats. J Pharmacol Exp Ther 201:399
Holtzman SG, Jewett RE (1971) The role of brain norepinephrine in the anorexic effect of dextroamphetamine and monoamine oxidase inhibitors in the rat. Psychopharmacology 22:151–161
Jackson DM, Andén N-E, Dahlstrom A (1975) A functional effect of dopamine in the nucleus accumbens and in some other dopamine-rich parts of the rat brain. Psychopharmacology 45:139–149
Kelly PH, Seviour PW, Iversen SD (1975) Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res 94:507–522
Koob GF, Riley ST, Smith SC, Robbins TW (1978) Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity and amphetamine anorexia in the rat. J Comp Physiol Psychol 92:917–927
Kullback S (1968) Information theory and statistics. Dover, New York
Lyon M, Robbins TW (1975) The action of central nervous system stimulant drugs: a general theory concerning amphetamine effects. In: Essman WB, Valzelli L (eds) Current developments in psychopharmacology, vol 2. Spectrum Publications, pp 79–163
Pellegrino LJ, Cushman AJ (1967) A stereotaxic atlas of the rat brain. Appleton-Century-Crofts, New York
Robbins TW (1977) A critique of the methods available for the measurement of spontaneous locomotor activity. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology, vol 7. Plenum Press, New York, pp 37–82
Segal DS (1975) Behavioural characterization of d- and l-amphetamine: neurochemical implications. Science 190:475–477
Tordoff MG, Hopfenbeck J, Butcher LL, Novin D (1982) A peripheral locus for amphetamine anorexia. Nature 297:148–150
Winer BJ (1971) Principles in experimental design. McGraw-Hill, New York, p 193
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Joyce, E.M., Iversen, S.D. Dissociable effects of 6-OHDA-induced lesions of neostriatum on anorexia, locomotor activity and stereotypy: The role of behavioural competition. Psychopharmacology 83, 363–366 (1984). https://doi.org/10.1007/BF00428546
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DOI: https://doi.org/10.1007/BF00428546