Abstract
Three expreiments are reported which examine the effects of lesions of the dorsal ascending noradrenergic bundle (DB) on latent inhibition using a conditioned suppression procedure in rats. In none of the experiments did the DB lesion have any effect, despite changes in the extent of latent inhibition and in the control procedures used to assess it. The results are discussed in relation to the attentional theory of DB function.
Similar content being viewed by others
References
Ackil JE, Mellgren RL, Halgren C, Frommer GP (1969) Effect of CS preexposure on avoidance learning in rats with hippocampal lesions. J Comp Physiol Psychol 69:739–747
Blakeley AGH, Dearnaley DP, Harrison V (1970) The noradrenaline content of the vas deferens of the guinea-pig. Proc R Soc Lond [Biol] 174:491–502
Jonsson G, Hallman H, Ponzio F, Ross SB (1981) DSP4 (N-2-cloroethyl-N-ethyl-bromobenzylamine) — A useful denervation tool for central and peripheral noradrenaline neurons. Eur J Pharmacol 72:173–188
Lorden JF, Rickert EJ, Berry DW (1983) Forebrain monoamines and associative learning: 1. Latent inhibition and conditioned inhibition. Behav Brain Res 9:181–199
Lorden JF, Rickert EJ, Dawson R, Pelleymounter MA (1980) Forebrain norepinephrine and the selective processing of information. Brain Res 190:569–573
Lubow RE (1973) Latent inhibition. Psychol Bull 79:398–407
Lubow RE, Schnur P, Rifkin B (1976) Latent inhibition and conditioned attention theory. J Exp Psychol [Anim Behav] 2:163–174
Mackintosh NJ (1983) Conditioning and associative learning. Oxford University Press, New York
Mason ST (1980) Noradrenaline and selective attention: a review of the model and the evidence. Life Sci 27:617–631
Mason ST (1981) Noradrenaline in the brain: progress in theories of behavioural function. Prog Neurobiol 16:263–303
Mason ST, Iversen SD (1979) Theories of the dorsal bundle extinction effect. Brain Res Rev 1:107–137
Mason ST, Lin D (1980) Noradrenaline and selective attention in the rat. J Comp Physiol Psychol 94:819–832
McFarland DJ, Kostas J, Drew WG (1978) Dorsal hippocampal lesions: Effects of preconditioning CS exposure on flavor aversion. Behav Biol 22:398–404
Millenson JR (1975) Systems developments in the ACT language: Towards machine independence. Behav Res Methods and Instrumentation 7:165–173
Mohammed AK, Everitt BJ, Dunn LT, Robbins TW, Kilbourn A, Archer T (1983) Noradrenaline and the latent inhibition effect in rats. 5th Catecholamine Symposium, Goteburg, Abstract 338. In: Supplement to Prog Neuropsychopharmacol Biol Psychiatr
Robbins TW, Everitt BJ, Fray PJ, Gaskin M, Carli M, de la Riva C (1982) The roles of the central catecholamines in attention and learning. In: Spiegelstein MY, Levy A (eds) Behavioral models and the analysis of drug action. Proceedings of the 27th OHOLO conference, Elsevier, Amsterdam pp 109–134
Solomon PR, Moore JW (1975) Latent inhibition and stimulus generalisation of the classically-conditioned nictitating membrane response in rabbits (Oryctolagus cuniculus) following dorsal hippocampal ablation. J Comp Physiol Psychol 89:1192–1203
Tsaltas E (1983) The role of the dorsal noradrenergic bundle in anxiety and selective attention. D. Phil. thesis, University of Oxford
Tsaltas E, Preston GC, Gray JA (1983) The effects of dorsal bundle lesions on serial and trace conditioning. Behav Brain Res 10:361–374
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tsaltas, E., Preston, G.C., Rawlins, J.N.P. et al. Dorsal bundle lesions do not affect latent inhibition of conditioned suppression. Psychopharmacology 84, 549–555 (1984). https://doi.org/10.1007/BF00431465
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00431465