Abstract
In two experiments tolerance development to the effects of arecoline on operant responding for a water reward was shown to be dose-dependent, complete tolerance developing to a daily dose of 4 mg/kg, but only partial tolerance developing to a daily dose of 8 mg/kg. However, rats chronically treated with the higher dose of arecoline were least affected by a challenge dose of oxotremorine (0.2 mg/kg); i.e. the high dose group exhibited the greatest cross-tolerance to oxotremorine. Moreover, atropine (4 mg/kg) pretreatment prior to arecoline (4 mg/kg) prevented cross-tolerance to oxotremorine, indicating that dispositional mechanisms are unlikely to be involved in tolerance to arecoline.
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References
Bartus RT, Dean RL, Beer B (1980) Memory deficit in aged Cebus monkeys and facilitation with central cholinomimetics. Neurobiol Aging 2:145–152
Flood JF, Smith GE, Cherkin A (1984) Memory retention test performance in mice: Improvement by chronic oral cholinergic drug treatment. Pharmacol Biochem Behav 21:169–173
Harbaugh RE, Roberts DW, Coombs DW, Sanders RL, Reeder TM (1984) Preliminary report: Intracranial cholinergic drug infusion in patients with Alzheimer's Disease. Neurosurgery 15:514–518
Majocha R, Baldessarini RJ (1984) Tolerance to an anticholinergic agent is paralleled by increased binding to muscarinic receptors in rat brain and increased behavioural response to a centrally active cholinomimetic. Life Sci 35:2247–2255
Meltzer LT, Rosecrans JA (1982) Tolerance to the disruptive effects of arecoline on schedule-controlled behavior. Psychopharmacology 77:85–93
Overstreet DH, Russell RW (1982) Selective breeding for sensitivity to diisopropyl fluorophosphate. Effects of agonists and antagonists. Psychopharmacology 78:150–155
Pradhan SN, Dutta SN (1970) Behavioral effects of arecoline in rats. Psychopharmacologia 17:49–58
Sitaram N, Weingartner H, Gillin JC (1978) Human serial learning: Enhancement with arecholine and choline and impairment with scopolamine. Science 201:274–276
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Overstreet, D.H., Jamal, O.S. Behavioural tolerance to arecoline in rats: Cross-tolerance to oxotremorine and prevention by pretreatment with atropine. Psychopharmacology 89, 118–120 (1986). https://doi.org/10.1007/BF00175202
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DOI: https://doi.org/10.1007/BF00175202