Abstract
A state-dependency procedure is described in which changes from the chlordiazepoxide state yield a robust and dose-dependent response decrement in rats. The format of data that are obtained with this procedure permits that the response decrement following a state change be defined accurately in individual animals, and that transfer be quantified. Dose-response studies revealed 13 (7.4–22) mg/kg to be the ED50 of chlordiazepoxide at which transfer occurred in animals that had acquired the response with 40 mg/kg chlordiazepoxide; the ED50 acquisition dose of chlordiazepoxide at which transfer to saline failed to occur was 3.7 (2.2–6.4 mg/kg).
This is a preview of subscription content, log in via an institution to check access.
References
Belleville RE (1964) Control of behavior by drug-produced internal stimuli. Psychopharmacologia 5:95–105
Colpaert FC, Niemegeers CJE, Janssen PAJ (1976) Theoretical considerations on drug discrimination learning. Psychopharmacologia 46:169–177
Finney DJ (1971) Statistical methods in biological assay, 2nd ed., Griffin Press, London
Koek W, Slangen J (1982) Drug stimulus generalization in the absence of discrimination training. In: Colpaert FC, Slangen J (eds) Drug discrimination: applications in CNS pharmacology, Elsevier Biomedical Press, Amsterdam, pp 263–268
Overton D (1966) State-dependent learning produced by depressant and atropine-like drugs. Psychopharmacologia 10:6–31
Overton D (1982) Memory retrieval failures produced by changes in drug state. In: Isaacson RL, Spear NE (eds) The expression of knowledge; neurobehavioral transformations of information into action, Plenum Press, New York, pp 113–139
Overton D (1983) State-dependent learning and drug discrimination. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of Psychopharmacology, Plenum Press, New York, Vol 18, pp 59–127
Siegel S (1956) Nonparametric statistics (McGraw-Hill, New York)
Weingartner H (1978) Human state dependent learning. In: Ho BT, Richards DW III, Chute DL (eds) Drug discrimination and state dependent learning, Academic Press, New York, pp 363–383
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Colpaert, F.C. A method for quantifying state-dependency with chlordiazepoxide in rats. Psychopharmacology 90, 144–146 (1986). https://doi.org/10.1007/BF00172887
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00172887