Abstract
Stimulation of muscarinic cholinergic receptors with the highly potent and selective receptor agonist oxotremorine produced hypothermia in rats. Alaproclate, a purported selective serotonergic reuptake inhibitor, potentiated this response. Destruction of central presynaptic serotonergic terminals with the potent cytotoxin p-chloroamphetamine (PCA) failed to attenuate the hypothermic response to oxotremorine in alaproclate-pretreated animals. These results could be taken to suggest that alaproclate may act, at least in part, via a non-serotonergic mechanism to potentiate the oxotremorine-induced hypothermic response.
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This work was completed when Dr. Dilsaver was on the faculty of the Department of Psychiatry at the University of Michigan
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Dilsaver, S.C., Normile, H.J. & Altman, H.J. Potentiation of oxotremorine-induced hypothermia by alaproclate in PCA lesioned and non-lesioned rats. Psychopharmacology 97, 51–53 (1989). https://doi.org/10.1007/BF00443412
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DOI: https://doi.org/10.1007/BF00443412