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Intranigral infusion of enkephalins elicits dyskinetic biting in rats

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Abstract

Leu- and Metenkephalin (Lenk and Menk) and their more stable analogues d-Ala-Leu- and d-Ala-Meten-kephalin (DALenk and DAMenk) as well as d-ala-d-Leu-and d-Ala-d-Metenkephalin (DADLenk and DADMenk) were infused bilaterally into substantia nigra in awake rats and oral movements were recorded for 90 min. DADLenk and DADMenk elicited dose-dependent biting dyskinesias with a chewing rate of about 90 jaw movements/min. DALenk produced a similar but weaker effect, whereas DAMenk, Lenk and Menk were ineffective in the doses given. These findings suggest a possible enkephalinergic mechanism underlying neuroleptic-induced tardive dyskinesias.

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Authors and Affiliations

  1. Psychiatric Research Centre, S-750 17, Uppsala, Sweden

    Ulla Liminga, Per Johansson & Lars M. Gunne

  2. Department of Pharmacology (F), University of Uppsala, S-750 17, Uppsala, Sweden

    Ingrid Nylander

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  1. Ulla Liminga
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  2. Per Johansson
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  3. Ingrid Nylander
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  4. Lars M. Gunne
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Liminga, U., Johansson, P., Nylander, I. et al. Intranigral infusion of enkephalins elicits dyskinetic biting in rats. Psychopharmacology 99, 299–303 (1989). https://doi.org/10.1007/BF00445547

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  • DOI: https://doi.org/10.1007/BF00445547

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