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Blockade of 8-OH-DPAT-induced feeding by dopamine antagonists

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Abstract

Feeding elicited by the 5HT1A agonist 8-OH-DPAT was blocked by pretreatment with the DA antagonists SCH-23390 and sulpiride, in two experiments conducted in non-deprived rats and in three experiments conducted after 4 h food deprivation. In deprived animals, 8-OH-DPAT prolonged the initial period of feeding. However, in non-deprived animals, 8-OH-DPAT delayed the onset of eating, and suppressed post-prandial resting; both SCH-23390 and sulpiride restored the normal pattern of behaviour. All three drugs suppressed grooming. The results suggest that 8-OH-DPAT elicits feeding by a secondary disinhibition of activity postsynaptic to DA neurons. The consequences of this mechanism for the interpretation of 8-OH-DPAT-induced feeding are discussed.

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  1. Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK

    Richard Muscat, Anthony M. J. Montgomery & Paul Willner

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  1. Richard Muscat
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  2. Anthony M. J. Montgomery
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  3. Paul Willner
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Muscat, R., Montgomery, A.M.J. & Willner, P. Blockade of 8-OH-DPAT-induced feeding by dopamine antagonists. Psychopharmacology 99, 402–408 (1989). https://doi.org/10.1007/BF00445567

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  • DOI: https://doi.org/10.1007/BF00445567

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