Abstract
The effects of pre-session and post-session daily ethanol injections on the development and loss of tolerance to ethanol's effects on fixed ratio operant performance in rats was assessed using a cumulative dosing procedure. Daily pre-session ethanol administration produced a greater decrease in ethanol sensitivity than did daily post-session ethanol. Both tolerance effects persisted for at least 1 month after the chronic injection phase. No changes in ethanol sensitivity were apparent in the saline control group and no changes in estimated blood ethanol levels were found after the chronic treatments. The post-session ethanol groups displayed a performance decrement during the initial segment of the chronic injection period, but improved significantly across the chronic phase. These data suggest that some delayed effect of ethanol initially impaired performance but that tolerance to this ethanol effect also occurred and probably contributed to the decline in ethanol sensitivity seen in these groups. Compensatory learning as the mechanism for tolerance development in the pre-session and post-session ethanol groups was supported by the finding of no change in ethanol sensitivity in rats exposed to comparable daily ethanol without any concurrent operant task on which the direct, immediate, or indirect, delayed ethanol effects could operate.
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References
Bird DC, Holloway FA (1989) Development and loss of tolerance to the effects of ethanol on DRL performance of rats. Psychopharmacology 97:45–50
Bird DC, Holloway FA, Carney JM (1985) Schedule-controlled behavior as an index of the development and loss of ethanol tolerance in the rat. Psychopharmacology 87:414–420
Chen CS (1968) A study of the alcohol tolerance effect and an introduction of a new behavioral technique. Psychopharmacologia 12:433–440
Demellweek C, Goudie AJ (1983) Behavioural tolerance to amphetamine and other psychostimulants. The case for considering behavioural mechanisms. Psychopharmacology 80:287–307
Emmett-Oglesby MW, Spencer DG, Wood CM, Lal H (1984) Task-specific tolerance tod-amphetamine. Neuropharmacology 23:563–568
Gallaher EJ, Egner DA (1987) Rebound hypothermia follows ethanol-induced hypothermia in rats. Psychopharmacology 91:34–39
Goudie AJ (1989) Behavioural techniques for assessing drug tolerance and sensitization. In: Boulton AA, Baker GB, Greenshaw AJ (eds) Psychopharmacology. Neuromethods Series, vol 13. Human Press, Clifton, New Jersey (in press)
Goudie AJ, Griffiths JW (1985) An interdisciplinary approach to drug tolerance. TIPS 6:355–356
Harland RD, Criado JR, Michaelis RC, Holloway FA (1987) Internal cues produced by ethanol or ethanol withdrawal: Generalization to anxiolytic and anxiogenic drugs. Soc Neurosci Abstr 13:340
Hinson RE, Siegel S (1980) The contribution of Pavlovian conditioning to ethanol tolerance and dependence. In: Rigter H, Crabbe JC (eds) Alcohol tolerance and dependence. Elsevier/North Holland Biomedical Press, Amsterdam, pp 181–199
Holloway FA, Bird DC, Holloway JA, Michaelis RC (1988) Behavioral factors in development of tolerance to ethanol's effects. Pharmacol Biochem Behav 29:105–113
Kalant H, Khanna JM (1980) Environmental-neurochemical interactions in ethanol tolerance. In: Sandler M (ed) Psychopharmacology of alcohol. Raven Press, New York, pp 107–120
Le AD, Kalant H, Khanna JM (1986) Influence of ambient temperature on the development and maintenance of tolerance to ethanol-induced hypothermia. Pharmacol Biochem Behav 25:667–672
LeBlanc AC, Gibbins RJ, Kalant H (1973) Behavioral augmentation of tolerance to ethanol in the rat. Psychopharmacologia 30:117–122
LeBlanc AE, Kalant H, Gibbins RJ (1976) Acquisition and loss of behaviorally augmented tolerance to ethanol in the rat. Psychopharmacology 48:153–158
Mansfield JG, Benedict RS, Woods SC (1983) Response specificity of behaviorally augmented tolerance to ethanol supports a learning interpretation. Psychopharmacology 79:94–98
McMaster SB, Carney JM (1986) Chronic exercise produces tolerance to muscarinic antagonists in rats. Pharmacol Biochem Behav 24:217–221
Melchior CL, Tabakoff B (1985) Features of environment-dependent tolerance to ethanol. Psychopharmacology 87:94–100
Mucha RF, Pinel JB (1979) Increased susceptibility to kindled seizures in rats after a single injection of alcohol. J Stud Alcohol 40:258–271
Pohorecky LA (1974) Effects of ethanol on central and peripheral noradrenergic neurons. J Pharmacol Exp Ther 189:380–391
Pohorecky LA, Brick J (1982) A new method for the determination of blood ethanol levels in rodents. Pharmacol Biochem Behav 16:693–696
Prim DR, Michaelis RC, Holloway FA (1986) Controlling operant behavior experiments with Commodore computers and PRO-MAL software: cost efficiency, “box bias,” and speed. Soc Neurosci Abstr 12:909
Redmond GP, Cohen G (1972) Sex differences in acetaldehyde exhalation following ethanol administration in C57/BL mice. Nature 236:117–119
Rydberg U (1977) Experimentally-induced alcohol hangover. Recent advances in the study of alcoholism. In Excerpta Medical International Congress, Series No. 407, pp 32–40
Schuster CR, Dockens WS, Woods JH (1966) Behavioral variables affecting the development of amphetamine tolerance. Psychopharmacologia 9:170–182
Sinclair JD, Gustafsson K (1987) Behavioral changes in rats on the day after acute ethanol intoxication. Alcohol 4:503–507
Sinclair JD, Taira T (1988) Hangover hypothermia in rats: relation to tolerance and external stimuli. Psychopharmacology 94:161–166
Sinclair JD, Gustafsson K, Aalto J (1984) Hangover and the effects in rats on the day after a single ethanol injection. Acta Pharmacol Toxicol [Suppl 1] 55:4
Sinclair JD, Gustafsson K, Taira T (1986) After-effects in rats of acute ethanol: influence of administration route, tolerance, and the procedure for measuring body temperature. Alcohol Alcoholism 21:44
Torres A, Michaelis RC, Holloway KJ, Holloway FA (1986) A method for determining ethanol and acetaldehyde components from expired air samples in rats. Soc Neurosci Abstr 12:286
Wenger JR (1981) Cumulative dose-response curves in behavioral pharmacology. Pharmacol Biochem Behav 13:647–651
Wenger JR, Berlin V, Woods SC (1980a) Learned tolerance to the behaviorally disruptive effects of ethanol. Behav Neural Biol 28:418–430
Wenger JR, Tiffany TM, Woods SC (1980b) Comparison of learned and unlearned factors in the acquisition of behavioral tolerance to ethanol. In: Eriksson K, Sinclair JD, Kiianmaa K (eds) Animal models in alcohol research. Academic Press, London, pp 351–356
Wenger JR, Tiffany TM, Bombardier C, Nicholls K, Woods SC (1981) Ethanol tolerance in the rat is learned. Science 213:575–577
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Holloway, F.A., King, D.A., Michaelis, R.C. et al. Tolerance to ethanol's disruptive effects on operant behavior in rats. Psychopharmacology 99, 479–485 (1989). https://doi.org/10.1007/BF00589895
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DOI: https://doi.org/10.1007/BF00589895