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Effects of a gastro-secretory substance from hog pancreas (GSP) and gastrin on bile secretion of the rat

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Summary

The effect of GSP, a gastrosecretagogue fraction extracted from hog pancreas, on bile secretion has been studied in rats provided with a bile duct canula and compared with the effect of antral gastrin. GSP showed no effect on bile secretion, concentration and output of bilirubin and electrolytes in the bile. On the other hand gastrin is significantly increasing bile output, bilirubin concentration and output in the bile. No effect of gastrin on the excretion rate of sodium and potassium in the bile has been observed.

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References

  1. Bombeck, C. T., Pissidis, A. G., Nyhus, L. M.: The choleretic action of gastrin: studies in the intact animal and the isolated perfused liver. Gastroenterology54, 1290 (1968)

    Google Scholar 

  2. Clodi, P. H., Schnack, H.: The influence of enterohormones (secretin, pancreozymin) on the secretion and composition of bile in the isolated perfused rat liver. Liver Research, pp. 418–422. Bruges: St. Catherine Press Ltd. 1967

    Google Scholar 

  3. Debray, Ch., de La Tour, J., Vaille, Ch., Rozé, C., Souchard, M.: Contribution à l'étude de la sécrétion biliaire et pancréatique externe chez le rat. J. Physiol. (Paris)54, 459–499 (1962)

    Google Scholar 

  4. Debray, Ch., Vaille, Ch., Vasseur, B., de La Tour, J., Rozé, C., Souchard, M.: Action d'une gastrine de porc et du pentapeptide gastrinique sur les sécrétions pancréatique et biliaire du rat anesthesié. Sem. Hôp.47, 2015–2022 (1971)

    Google Scholar 

  5. Gordon, E. M., Douglas, M. C., Jablonski, P., Owen, J. A., Sali, A.: Gastroduodenal hormones and bile secretion studies in the isolated perfused pig liver. Surgery72, 708–721 (1972)

    Google Scholar 

  6. Gregory, R. A., Tracy, H. J.: The constitution and properties of two gastrins extracted from hog antral mucosa. Gut5, 103–114 (1964)

    Google Scholar 

  7. Jones, R. S., Grossman, M. I.: The choleretic effect of cholecystokinin, gastrin II, and caerulein in the dog. Amer. J. Physiol.219, 1014–1018 (1970)

    Google Scholar 

  8. Kowalewski, K.: The effect of histamine and pentagastrin on the secretion of bile in rats. Arch. int. Pharmacodyn.200, 370–377 (1972)

    Google Scholar 

  9. Lai, K. S.: Studies on gastrin. Gut5, 327–333 (1964)

    Google Scholar 

  10. Pointner, H., Vatier, J., Dubrasquet, M., Accary, J. P., Bonfils, S.: Isolation of a gastrosecretagogue substance from hog pancreas. Clin. chim. Acta42, 321–326 (1972)

    Google Scholar 

  11. Touli, J., McWatts, J.: Actions of cholecystokinin/pancreozymin, secretin and gastrin on extrahepatic biliary tract motility in vitro. Ann. Surg.175, 439–447 (1972)

    Google Scholar 

  12. Zaterka, S., Grossman, M. I.: The effect of gastrin and histamin on secretion of bile. Gastroenterology50, 500–505 (1966)

    Google Scholar 

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With the assistance of the “Österreichischer Forschungsfonds”, project Nr. 1505.

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Pointner, H., Flegel, U. Effects of a gastro-secretory substance from hog pancreas (GSP) and gastrin on bile secretion of the rat. Pflugers Arch. 345, 73–79 (1973). https://doi.org/10.1007/BF00587063

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  • DOI: https://doi.org/10.1007/BF00587063

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