Abstract
The role of the renin-angiotensin system as a mediator of water intake, induced by hypovolemia after polyethylene glycol (PEG) injection, was investigated. Blockade of angiotensin I converting enzyme and of angiotensin receptors was used as a pharmacological tool. A significant reduction of water intake was observed when angiotensin 1 converting enzyme was inhibited by captopril and enalapril. In PEG-treated rats with blockade of angiotensin I converting enzyme, hypertonic saline injection continued to elicit substantial drinking. Normalization of low blood pressure by vasopressin infusions in PEG and captopril treated rats did not interfere with the antidipsogenic effectiveness of converting enzyme blockade. The angiotensin II receptor antagonist, saralasin, also reduced PEG-induced drinking although less effectively than converting enzyme inhibitors. We conclude that water intake due to isotonic depletion of the extracellular fluid compartment may depend on the activity of the renin-angiotensin system.
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References
Andersson B (1978) Regulation of water intake. Physiol Rev 58:582–603
Blass EM, Fitzsimons JT (1970) Additivity of effect and interaction of a cellular and an extracellular stimulus of drinking. J Comp Physiol 70:200–205
Elfont RM, Fitzsimons JT (1983) Renin dependence of captopril-induced drinking after ureteric ligation in the rat. J Physiol 343:17–30
Evered MC, Robinson MM (1981) The renin-angiotensin system in drinking and cardiovascular responses to isoprenaline in the rat. J Physiol 316:357–367
Fitzsimons JT (1961) Drinking by nephrectomized rats injected with various substances. J Physiol (Lond) 155:563–579
Fitzsimons JT, Elfont RM (1982) Angiotensin does contribute to drinking induced by caval ligation in rat. Am J Physiol 243:R558-R562
Fitzsimons JT, Kucharcyk J, Richards G (1978) Systemic angiotensin-induced drinking in the dog: a physiological phenomenon. J Physiol 276:435–448
Hosutt JA, Rowland N, Stricker EM (1981) Impaired drinking responses of rats with lesions of the subfornical organ. J Comp Physiol Psychol 95:104–113
Johnson AK, Mann JFE, Rascher W, Johnson K, Ganten D (1981) Plasma angiotensin II concentration and experimentally-induced thirst. Am J Physiol 240:R229-R234
Katovich MJ, Barney CC, Fregly MJ, McCaa RE (1979) Effect of an angiotensin converting enzyme inhibitor (SQ 14, 225) on β-adrenergic and angiotensin-induced thirst. Eur J Pharmacol 56:123–130
Mann JFE, Johnson AK, Ganten D (1980) Plasma angiotensin II: Dipsogenic levels and the angiotensin generating capacity of renin. Am J Physiol 238:R372–377
Mann JFE, Johnson AK, Rascher W, Genest J, Ganten D (1981) Thirst in the rat after ligation of the inferior vena cava: Role of angiotensin II. Pharmacol Biochem Behav 15:337–341
Mann JFE, Johnson AK, Ganten D, Ritz E, (1987) Thirst and the renin-angiotensin system. Kidney Int 32: S-27–S-34
Robinson MM, Evered MD (1986) Pressure dependence of angiotensin induced thirst. In: de Caro G, Epstein AN, Massi M (eds). The physiology of thirst and sodium appetite. Plenum Press, New York, pp 193–198
Simpson JB, Epstein AN, Camardo JS Jr (1978) Localization of receptors for the dipsogenic action of angiotensin II in the subfornical organ of rat. J Comp Physiol Psychol 92:581–608
Stricker EM (1978) Excessive drinking by rats with septal lesions during hypovolemia induced by subcutaneous colloid treatment. Physiol Behav 21:905–907
Stricker EM, Bradshaw WG, McDonald RH jr (1976) The renin-angiotensin system and thirst: A re-evaluation. Science 194:1169–1171
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Mann, J.F.E., Eisele, S., Tettig, R. et al. Renin-dependent water intake in hypovolemia. Pflugers Arch. 412, 574–578 (1988). https://doi.org/10.1007/BF00583757
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DOI: https://doi.org/10.1007/BF00583757