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The molecular electrostatic potential of the B-DNA helix

IV. C8 and amino sites of purines and the binding of carcinogenic acetylaminofluorene to DNA

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Abstract

The influence of a single and double helical DNA environment on the molecular electrostatic potentials at the C8 and amino sites of guanine and adenine are studied. The results are employed in a tentative explanation of the variation in binding sites of N-acetoxy-N-2-acetylaminofluorene with DNA, following whether the nucleic acid is in a native or denatured state.

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  1. Laboratoire de Biochimie Théorique associé au C.N.R.S., Institut de Biologie Physico-Chimique, 13, rue P. et M. Curie, F-75005, Paris, France

    Richard Lavery & Bernard Pullman

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  1. Richard Lavery
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  2. Bernard Pullman
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Lavery, R., Pullman, B. The molecular electrostatic potential of the B-DNA helix. Theoret. Chim. Acta 53, 175–181 (1979). https://doi.org/10.1007/BF00548830

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  • DOI: https://doi.org/10.1007/BF00548830

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