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Chiral capillary HPLC and HPLC-MS: New applications of chemically bonded β-cyclodextrin as stationary phase

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Abstract

Chemically bonded β-cyclodextrin (ChiraDex®) has been packed into 0.25 mm i.d. capillaries and used for the enantiomer separation of several pharmaceuticals by capillary HPLC with UV and electrospray ionization (ESI) MS detection. While having several advantages over conventional HPLC, capillary HPLC yielded comparable results, e.g. with respect to resolution and sensitivity. The good compatibility to ESI-MS was demonstrated.

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Author notes

  1. Martin Jung

    Present address: Ciba-Geigy A6, Pharmaceutical Research, CH-4002, Basel, Switzerland

Authors and Affiliations

  1. E. Merck, LAB Chrom 1, Frankfurter Strasse 250, D-64293, Darmstadt, Germany

    Karin Cabrera

  2. Institut für Organische Chemie, Auf der Morgenstelle 18, D-72076, Tübingen, Germany

    Martin Jung, Christoph Kempter & Volker Schurig

Authors
  1. Karin Cabrera
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  2. Martin Jung
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  3. Christoph Kempter
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  4. Volker Schurig
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Additional information

Dedicated to Professor Dr. Dr. h.c. mult. J.F.K. Huber on the occasion of his 70th birthday

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Cabrera, K., Jung, M., Kempter, C. et al. Chiral capillary HPLC and HPLC-MS: New applications of chemically bonded β-cyclodextrin as stationary phase. Fresenius J Anal Chem 352, 676–678 (1995). https://doi.org/10.1007/BF00323046

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  • DOI: https://doi.org/10.1007/BF00323046

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