Summary
The enantiomeric separation ability of unmodified and methylated cyclodextrins (CDs) during capillary zone electrophoresis (CZE) was investigated using twelve dansylamino acids. Unmodified β- and γ-CDs exhibited high enantioselectivities. α-CD could scarcely separate the enantiomers before and after dimethylation, but obtained enantioselectivity after trimethylation. On the other hand, dimethylation of β-CD removed much of its high enantioselectivity. Moreover, the chemical modifications produced a reverse in the migration order of the enantiomers. The inclusion of dansyl-DL-phenylalanine with CDs was evaluated using 600 MHz 1H NMR spectroscopy.
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Tanaka, M., Yoshinaga, M., Asano, S. et al. Enantiomeric separation of dansylamino acids by capillary zone electrophoresis based on complexation with cyclodextrins. Fresenius J Anal Chem 343, 896–900 (1992). https://doi.org/10.1007/BF00321962
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DOI: https://doi.org/10.1007/BF00321962