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The vestibulospinal tract: Crossed and uncrossed effects on hindlimb motoneurones in the cat

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Summary

Effects produced by stimulation of Deiters' nucleus on contralateral hindlimb motoneurones were investigated in the cat with intracellular and monosynaptic reflex recording. Polysynaptic PSPs were evoked in all species of motoneurone examined. The minimal synaptic linkage was found to be disynaptic in the excitatory path and trisynaptic in the inhibitory path. Experiments with various lesions to the spinal funiculus and those with mapping of the stimulated sites in the brain stem showed that the effects were evoked almost exclusively via the lateral vestibulospinal tract of the stimulated side.

The crossed effects were excitatory in extensor motoneurones of all species studied except for hip extensors (ABSm) in which EPSPs and/or IPSPs were evoked. The effects on flexors, by contrast, were not simple and consisted of EPSPs, IPSPs or a mixture of both. The difference in effects depended, though not entirely, on the species of motor nucleus. Between the excitatory and inhibitory effects on knee flexor (PBSt) motoneurones the former predominated under chloralose and the latter under pentobarbital anaesthesia. By recording PSPs evoked from the two vestibulospinal tracts in the same motoneurone, the convergence pattern and the magnitude of effects from the two tracts were studied.

The interneuronal organization of the crossed vestibulo-motoneuronal pathway and its functional significance are discussed.

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References

  • Akaike, T.: Comparison of neuronal composition of the vestibulospinal system between cat and rabbit. Exp. Brain Res. 18, 429–432 (1973)

    Google Scholar 

  • Akaike, T., Fanardjian, V.V., Ito, M., Kumada, M., Nakajima, H.: Eleetrophysiologioal analysis of the vestibulospinal reflex pathway of rabbit. I. Classification of tract cells. Exp. Brain Res. 17, 477–496 (1973)

    Google Scholar 

  • Akaike, T., Fanardjian, V.V., Ito, M., Ohno, T.: Electrophysiological analysis of the vestibulospinal reflex pathway of rabbit. II. Synaptic actions upon spinal neurones. Exp. Brain Res. 17, 497–515 (1973)

    Google Scholar 

  • Baldissera, F., Weight, F.: Descending monosynaptic connexions to spinal border cells. Acta physiol. scand. 76, 28–29A (1969)

    Google Scholar 

  • Brodal, A., Pompeiano, O., Walberg, F.: The vestibular nuclei and their connections anatomy and functional correlations. Edinburgh: Oliver and Boyd 1962

    Google Scholar 

  • Bruggencate, G.T., Lundberg, A.: Facilitatory interaction in transmission to motoneurones from vestibulospinal fibres and contralateral primary afferents. Exp. Brain Res. 19, 248–270 (1974)

    Google Scholar 

  • Busch, H.F.M.: An anatomical analysis of the white matter in the brain stem of the cat. Thesis, Van Gorcum, Assen 1961

    Google Scholar 

  • Curthoys, I.S., Markham, C.H.: Convergence of labyrinthine influences on units in the vestibular nuclei of the cat. I. Natural stimulation. Brain Res. 35, 469–490 (1971)

    Google Scholar 

  • Eccles, J.C., Eccles, R.M., Lundberg, A.: The convergence of monosynaptic excitatory afferents on to many different species of alpha motoneurones. J. Physiol. (Lond.) 137, 22–50 (1957)

    Google Scholar 

  • Eccles, R.M., Lundberg, A.: Integrative pattern of Ia synaptic actions on motoneurones of hip and knee muscles. J. Physiol. (Lond.) 144, 271–298 (1958)

    Google Scholar 

  • Grillner, S., Hongo, T.: Vestibulospinal effects on motoneurones and interneurones in the lumbosacral cord. In: Basic aspects of central vestibular mechanisms. (Ed. A. Brodal, O. Pompeiano), p. 243–262. Amsterdam: Elsevier Publ. Co. 1972

    Google Scholar 

  • Grillner, S., Hongo, T., Lund, S.: Interaction between the inhibitory pathways from the Deiters' nucleus and Ia afferents to flexor motoneurones. Acta physiol. scand. 68, Suppl.277, 61 (1966)

    Google Scholar 

  • Grillner, S., Hongo, T., Lund, S.: The origin of descending fibres monosynaptically activating spinoreticular neurones. Brain Res. 10, 259–262 (1968)

    Google Scholar 

  • Grillner, S., Hongo, T., Lund, S.: Descending monosynaptic and reflex control of γ-motoneurones. Acta physiol. scand. 75, 592–613 (1969)

    Google Scholar 

  • Grillner, S., Hongo, T., Lund, S.: The vestibulospinal tract. Effects on alpha-motoneurones in the lumbosacral spinal cord in the cat. Exp. Brain Res. 10, 94–120 (1970)

    Google Scholar 

  • Hongo, T., Jankowska, E.: Effects from the sensorimotor cortex on the spinal cord in cats with transected pyramids. Exp. Brain Res. 3, 117–134 (1967)

    Google Scholar 

  • Hongo, T., Kudo, N., Tanaka, R.: Effects from the vestibulospinal tract on the contralateral hindlimb motoneurones in the cat. Brain Res. 31, 220–223 (1971)

    Google Scholar 

  • Hultborn, H., Udo, M.: Convergence in the reciprocal Ia inhibitory pathway of excitation from descending pathways and inhibition from motor axon collaterals. Acta physiol. scand. 84, 95–108 (1972)

    Google Scholar 

  • Ito, M., Hongo, T., Okada, Y.: Vestibular-evoked postsynaptic potentials in Deiters neurones. Exp. Brain Res. 7, 214–230 (1969)

    Google Scholar 

  • Ito, M., Hongo, T., Yoshida, M., Okada, Y., Obata, K.: Antidromic and trans-synaptic activation of Deiters' neurones induced from the spinal cord. Jap. J. Physiol. 14, 638–658 (1964)

    Google Scholar 

  • Ito, M., Yoshida, M.: The origin of cerebellar-induced inhibition of Deiters neurones. I. Monosynaptic initiation of the inhibitory postsynaptic potentials. Exp. Brain Res. 2, 330–349 (1964)

    Google Scholar 

  • Jankowska, E., Lindström, S.: Morphology of interneurones mediating Ia reciprocal inhibition of motoneurones in the spinal cord of the cat. J. Physiol. (Lond.) 226, 805–823 (1972)

    Google Scholar 

  • Jankowska, E., Lundberg, A., Roberts, W.J., Stuart, D.: A long propriospinal system with direct effect on motoneurones and on interneurones in the cat lumbosacral cord. Exp. Brain Res. 21, 169–194 (1974)

    Google Scholar 

  • Jankowska, E., Roberts, W.J.: Synaptic actions of single interneurones mediating reciprocal Ia inhibition of motoneurones. J. Physiol. (Lond.) 222, 623–642 (1972)

    Google Scholar 

  • Ladpli, R., Brodal, A.: Experimental studies of commisural and reticular formation projections from the vestibular nuclei in the cat. Brain Res. 8, 65–96 (1968)

    Google Scholar 

  • Lund, S., Pompeiano, O.: Monosynaptic excitation of alpha motoneurones from supraspinal structures in the cat. Acta physiol. scand. 73, 1–21 (1968)

    Google Scholar 

  • Maeda, M., Maunz, R.A., Wilson, V.J.: Labyrinthine influence on eat forelimb motoneurons. Exp. Brain Res. 22, 69–86 (1975)

    Google Scholar 

  • Matsushita, M.: Some aspects of the interneuronal connections in cat's spinal gray matter. J. comp. Neurol. 136, 57–80 (1969)

    Google Scholar 

  • Nagaki, J.: Some observations of the tonic labyrinthine reflex on extensor and flexor muscles in the forelimb of the cat. Kumamoto med. J. 25, 117–121 (1972)

    Google Scholar 

  • Nyberg-Hansen, R.: Origin and termination of fibers from the vestibular nuclei descending in the medial longitudinal fasciculus. J. comp. Neurol. 122, 355–367 (1964)

    Google Scholar 

  • Nyberg-Hansen, R., Mascitti, T.A.: Sites and mode of termination of fibers of the vestibulospinal tract in the cat. An experimental study with silver impregnation methods. J. comp. Neurol. 122, 369–387 (1964)

    Google Scholar 

  • Orlovsky, G.N.: Activity of vestibulospinal neurons during locomotion. Brain Res. 46, 85–98 (1972)

    Google Scholar 

  • Rexed, B.: The cytoarchitectonic organization of the spinal cord in the cat. J. comp. Neurol. 96, 415–495 (1952)

    Google Scholar 

  • Roberts, T.M.D.: Changes in stretch reflexes in limb extensor muscle during position reflexes from the labyrinth in the cat. J. Physiol. (Lond.) 211, 5P (1970)

  • Rosenberg, J.R., Lindsay, K.W.: Asymmetric tonic labyrinthine reflex. Brain Res. 63, 347–350 (1973)

    Google Scholar 

  • Sasaki, K., Tanaka, T., Mori, K.: Effects of stimulation of pontine and bulbar reticular formation upon spinal motoneurons of the cat. Jap. J. Physiol. 12, 45–62 (1962)

    Google Scholar 

  • Scheibel, M.E., Scheibel, A.B.: Spinal motoneurones, interneurones and Renshaw cells. A Golgi study. Arch. ital. Biol. 104, 328–353 (1966)

    Google Scholar 

  • Shapovalov, A.I.: Excitation and inhibition of spinal neurones during supraspinal stimulation. Muscular afferents and motor control. (Ed. R. Granit), p. 331–348. Stockholm: Almqvist and Wiksell 1966

    Google Scholar 

  • Shapovalov, A.I.: Posttetanic potentiation of monosynaptic and disynaptic actions from supraspinal structures on lumbar motoneurones. J. Neurophysiol. 32, 948–959 (1969)

    Google Scholar 

  • Shimazu, H., Precht, W.: Inhibition of central vestibular neurones from the contralateral labyrinth and its mediating pathway. J. Neurophysiol. 29, 467–492 (1966)

    Google Scholar 

  • Shimazu, H., Smith, C.M.: Cerebellar and labyrinthine influences of single vestibular neurons identified by natural stimuli. J. Neurophysiol. 34, 493–508 (1971)

    Google Scholar 

  • Staal, A.: Subcortical projections of the spinal grey matter of the cat. Thesis, Koninklijke Drukkerijen, Lankhout, Immig N.V., 's. Gravenhage, Leiden 1961

    Google Scholar 

  • Wilson, V.J., Kato, M., Peterson, B.W., Wylie, R.M.: A single —unit analysis of the organization of Deiters' nucleus. J. Neurophysiol. 30, 603–619 (1967)

    Google Scholar 

  • Wilson, V.J., Maeda, M.: Connection between semicircular canals and neck motoneurons in the cat. J. Neurophysiol. 37, 346–357 (1974)

    Google Scholar 

  • Wilson, V.J., Yoshida, M.: Comparison of effects of stimulation of Deiters' nucleus and medial longitudinal fasciculus on neck, forelimb, and hindlimb motoneurons. J. Neurophysiol. 32, 743–758 (1969a)

    Google Scholar 

  • Wilson, V.J., Yoshida, M.: Bilateral connections between labyrinths and neck motoneurons. Brain Res. 13, 603–607 (1969b)

    Google Scholar 

  • Wilson, V.J., Yoshida, M., Schor, R.H.: Supraspinal monosynaptic excitation and inhibition of thoracic back motoneurons. Exp. Brain Res. 11, 282–295 (1970)

    Google Scholar 

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Author notes

  1. N. Kudo

    Present address: Department of Physiology, University of North Carolina, School of Medicine, 27514, Chapel Hill, N.C., USA

Authors and Affiliations

  1. Department of Physiology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan

    T. Hongo, N. Kudo &  R. Tanaka

  2. Laboratory of Physiology, Institute of Basic Medical Sciences, University of Tsukuba, Niihari-gun, Ibaraki-ken, Japan

    T. Hongo, N. Kudo &  R. Tanaka

  3. Department of Physiology, Faculty of Medicine, Hirosaki University, Hirosaki, Japan

    R. Tanaka

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Hongo, T., Kudo, N. & Tanaka, R. The vestibulospinal tract: Crossed and uncrossed effects on hindlimb motoneurones in the cat. Exp Brain Res 24, 37–55 (1975). https://doi.org/10.1007/BF00236016

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  • DOI: https://doi.org/10.1007/BF00236016

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