Skip to main content
SpringerLink
Log in

Intramuscular bioavailability of chlorazepate as compared to diazepam

  • Short Communications
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

Dipotassium chlorazepate (DPC) and diazepam (DZM) were given i.m. and i.v. to 6 healthy volunteers in doses of 20 mg (48.9 µmol) DPC and 15 mg (52.0 µmol) DZM. The interval between the injections was at least 1 week. Plasma samples were analyzed for DPC and DZM by HPLC. The bioavailability of DPC and DZM after i.m. administration, determined from computer calculated AUCs, was 1.04 and 0.85, respectively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Bellantuono C, Reggi U, Tognoni G, Garattini S (1980) Benzodiazepines: clinical pharmacology and therapeutic use. Drugs 19: 195–219

    Google Scholar 

  • Bertler Å, Lindgren S, Malmgren H (1980) Pharmacokinetics of dipotassium chlorazepate in patients after repeated 50 mg oral doses. Psychopharmacology 71: 165–167

    Google Scholar 

  • Bertler Å, Lindgren S, Magnusson J-O, Malmgren H (1983) Pharmacokinetic of chlorazepate after intravenous and intramuscular administration. Psychopharmacology 80: 236–239

    Google Scholar 

  • Hillestad L, Hansen T, Melsom H, Drivenes A (1974) Diazepam metabolism in normal man. I. Serum concentration and clinical effects after intravenous, intramuscular and oral administration. Clin Pharmacol Ther 16: 479–484

    Google Scholar 

  • Post C, Lindgren S, Bertler Å, Malmgren H (1977) Pharmacokinetics of N-desmethyldiazepam in healthy volunteers after single daily doses of dipotassium chlorazepate. Psychopharmacology 53: 105–109

    Google Scholar 

  • Rey E, d'Athis Ph, Giraux P, de Lauture D, Turquais LM, Chavinie J, Olive G (1979a) Pharmacokinetics of chlorazepate in pregnant and non-pregnant women. Eur J Clin Pharmacol 15: 175–180

    Google Scholar 

  • Staak M, Moosmayer A, Besserer K, Speidel K, Kleinschmidt A (1982) Pharmakokinetische Untersuchungen nach oraler und parenteraler Applikation von Dikalium-Chlorazepat. Arzneimittelforsch 32 [1]: 272–275

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology, University Hospital, University of Linköping and AB Leo, Helsingborg, Sweden

    Å. Bertler, S. Lindgren, J. -O. Magnusson & H. Malmgren

Authors
  1. Å. Bertler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Lindgren
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. -O. Magnusson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Malmgren
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bertler, Å., Lindgren, S., Magnusson, J.O. et al. Intramuscular bioavailability of chlorazepate as compared to diazepam. Eur J Clin Pharmacol 28, 229–230 (1985). https://doi.org/10.1007/BF00609698

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00609698

Key words

Search

Navigation