Summary
The absorption of nifedipine (10 mg) and haemodynamic response were studied in 10 patients with myocardial infarction before (Phase A) and after (Phase B) a standardized breakfast. In Phase A, the peak nifedipine concentration (Cmax) and maximum haemodynamic changes were found 1 h after drug administration. In Phase B, the Cmax was lower than that in phase A (43±6 vs 136±23 ng/ml,p<0.001), and both Cmax and maximum haemodynamic changes were delayed to the fourth hour after administration. Nifedipine plasma concentration correlated significantly with the percent changes in systolic and diastolic blood pressure and heart rate.
This study suggests that not only dose but also the time intervals between nifedipine administration and food intake are important in determining the haemodynamic effects.
References
Pitta P, Rava A, Biondi P (1981) High-performance liquid chromatography or nifedipine, its metabolites and photochemical degradation products. J Chromatogr 210: 516–521
Sadanaga T, Hikida K, Tamedo K, Matsushita Y, Ohkura Y (1982) Determination of nifedipine in plasma by high-performance liquid chromatography. Chem Pham Bull 30: 3807–3809
Zar JH (1974) Biostatistical analysis. Englwood Cliffs, Prentice-Hall, pp 236–248
Jokobson P, Pedersen OL, Mikkelsen E (1979) Gas chromatographic determination of nifedipine and one of its metabolites using electron-capture detection. J Chromatogr 162: 81–87
Foster TS, Hamann SR, Richards VR, Bryant PJ, Graves DA, McAllister RG Jr (1983) Nifedipine kinetics and bioavailability after single intravenous and oral doses in normal subjects. J Clin Pharmacol 23: 161–170
Welling PG (1977) Influence of food and diet on gastro-intestinal drug absorption: a review. J Pharmacokin et Biopharm 5: 291–334
Horster FA (1975) Pharmacokinetics of nifedipine —14C in man. In: Hashimoto K, Kimura E, Kobayashi T (eds) First International Adalat Symposium. Tokyo University of Tokyo, pp 67–70
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Hirasawa, K., Shen, W.F., Kelly, D.T. et al. Effect of food ingestion on nifedipine absorption and haemodynamic response. Eur J Clin Pharmacol 28, 105–107 (1985). https://doi.org/10.1007/BF00635716
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DOI: https://doi.org/10.1007/BF00635716