Summary
The kinetics of alprenolol, in relation to its effect on blood pressure and plasma renin activity, have been studied in sixteen patients. A within-patient comparison was made between therapy for six weeks with placebo or alprenolol 200 mg thrice daily. Thirteen patients responded to alprenolol by a significant fall in blood pressure. In three other patients treatment did not lower blood pressure. In the group as a whole there was no significant correlation between the fall in systolic, diastolic or mean blood pressure, and the steady-state plasma alprenolol concentration, renin status, or degree of beta blockade. However, the thirteen responsive patients showed a significant relationship (p<0.05 – 0.001) between the log mean steady-state plasma alprenolol concentration and the hypotensive response.
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Åblad, R., Johnsson, G., Norrby, A., Sölvell, L.: Potency and time effect relationship of propranolol and H 56/28 — comparative studies after oral administration. Acta pharmacol. (Kbh.),25 (Suppl. 2) 85 - 94 (1967)
Bengtsson, C.: Comparison between alprenolol and propranolol as antihypertensive agents. A double-blind cross-over study. Acta med. scand.192, 415 - 418 (1972)
Brunner, H.R., Laragh, J.H., Baer, L., Newton, M.A., Goodwin, F.T., Krakoff, L.R., Bard, R.H., Bühler, F.R.: Essential hypertension: Renin and aldosteron, heart-attack and stroke. New Engl. J. Med.286, 441- 449 (1972)
Bühler, F.R., Laragh, J.H., Baer, L., Vaughan, E.D., Brunner, H.R.: Propranolol inhibition of renin secretion. New Engl. J. Med.287, 1209 - 1214 (1972)
Castenfors, J., Johansson, H., Orö, L.: Effect of alprenolol on blood pressure and plasma renin activity in hypertensive patients. Acta med. scand.193, 189 - 195 (1973)
Collste, P., Haglund, K., Frisk-Holmberg, M., Orme, M.L.E., Rawlins, M.D.: Pharmacokinetics and pharmacodynamics of alprenolol in the treatment of hypertension. I. Relationship between plasma concentration and adrenergic beta-receptor blockade. Europ. J. clin. Pharmacol.10, 85 - 88 (1976)
Dollery, C.T., Lewis, P.J., Myers, M.G., Reid, J.L.: Central hypotensive effect of propranolol in the rabbit. Brit. J. Pharmacol.48, 343 (1973)
Dorph, S., Binder, C.: Evaluation of the hypotensive effect of beta-adrenergic blockade in hypertension. Acta med. scand.185, 443 - 448 (1969)
Ervik, M.: Gas chromatographic determination of the secondary amine alprenolol and its trifluoroacetyl derivative, at nanogram levels in biological fluids. Acta pharm. suec.6, 393- 400 (1969)
Frohlich, E.D., Tarazi, R.C., Dustan, H.P., Page, J.H.: The paradox of beta-adrenergic blockade in hypertension. Circulation38, 417 - 423 (1968)
Furberg, C., Michaelson, G.: Effect of Aptin, a beta-adrenergic blocking agent, in arterial hypertension. Acta med. scand.186, 447 - 450 (1969)
Hansson, L., Malmcrona, R., Olander, R., Rosenhall, L., Westerlund, A., Åberg, H., Hood, B.: Propranolol in hypertension. Report on 158 patients treated up to one year. Klin. Wschr.50, 364- 369 (1972)
Hansson, L.: Beta-adrenergic blockade in essential hypertension. Acta med. scand. Suppl.550, 1 - 40 (1973)
Kelliher, G.J., Buckley, J.P.: Central hypotensive action of dl- and d-propranolol. J. pharm. Sci.59, 1276 - 1280 (1970)
Leishman, A.W.D., Thirkettle, J.L., Allen, B.R., Dixon, R.A.: Controlled trial of oxprenolol and practolol in hypertension. Brit. med. J.1970 IV, 343- 344
Leonetti, G., Mayer, G., Morganti, A., Terzoli, L., Zanchetti, A., Bianchetti, G., Di Salle, E., Morselli, P.L., Chidsey, C.A.: Hypotensive and renin-suppressing activities of propranolol in hypertensive patients. Clin. Sci. Molec. Med.48, 491 - 499 (1975)
Orme, M.L.E., Collste, P.: Plasma renin activity in normal volunteers and hypertensive patients treated with alprenolol. A comparison between two different methods prior to radioimmunoassay. (In preparation)
Persson, I., Ulrich, J.: Treatment of hypertension with a new beta-blocker agent, pindolol (Visken®). Europ. J. clin. Pharmacol.6, 217 (1973)
Prichard, B.N.C., Gillam, P.M.S.: Use of propranolol (Inderal) in treatment of hypertension. Brit. med. J.1964 II, 725 - 727
Rawlins, M.D., Collste, P., Frisk-Holmberg, M., Östman. J., Sjöqvist, F.: Steady-state concentrations of alprenolol. Europ. J. clin. Pharmacol.7, 353 - 356 (1974)
Sealey, J.E., Laragh, J.H.: Searching out low renin patients: Limitations of some commonly used methods. Amer. J. Med.55, 303 - 314 (1973)
Snedecor, G.W., Cochran, W.C.: Statistical methods (6th Ed). Ames, Iowa: Iowa State University Press 1967
Tarazi, R.C., Dustan, H.P.: Beta-adrenergic blockade in hypertension. Amer. J. Cardiol.29, 633 - 640 (1972)
Tibblin, G., Åblad, B.: Antihypertensive therapy with alprenolol, a beta-adrenergic receptor antagonist. Acta med. scand.186, 451 - 457 (1969)
Waal-Manning, H.J.: Comparative studies on the hypotensive effects of beta-adrenergic receptor blockers. In: Simpson symposium on beta-adrenergic receptor blocking drugs, p. 64. Auckland: Ciba 1970
Winer, N., Chokshi, D.S., Yoon, M.S., Freedman, A.D.: Adrenergic receptor mediation of renin secretion. J. clin. Endocr.29, 1168 - 1175 (1969)
Zacharias, F.J., Cowen, K.J.: Controlled trial of propranolol in hypertension. Brit. med. J.1970 I, 471 - 474
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Collste, P., Haglund, K., Frisk-Holmberg, M. et al. Pharmacokinetics and pharmacodynamics of alprenolol in the treatment of hypertension. Eur J Clin Pharmacol 10, 89–95 (1976). https://doi.org/10.1007/BF00609465
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DOI: https://doi.org/10.1007/BF00609465