Summary
Sixteen patients with essential hypertension were treated with propranolol 160 to 640 mg daily for three months. Significant decreases both in recumbent and standing blood pressure were observed after three days treatment and subsequently. Reduction of blood pressure was more pronounced when the dose of propranolol was increased. However, neither the mean dose nor the plasma concentration of propranolol could be correlated with the mean decrease in blood pressure. There was great interindividual variation in the plasma concentrations of propranolol produced by the same daily dose. The initial stimulation of plasma renin activity and the therapeutic response to propranolol could not be correlated.
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References
Berglund, G., Andersson, O., Hansson, L., Olander, R.: Propranolol given twice daily in hypertension. Acta med. scand.194, 513–515 (1973)
Bühler, F. R., Laragh, J. H., Vaughan, E. D., Brunner, H. R., Gavras, H., Baer, L.: Antihypertensive action of propranolol. Amer. J. Cardiol.32, 511–522 (1973)
Chidsey, C. A., Morselli, P., Bianchetti, G., Morganti, A., Leonetti, G., Zanchetti, A.: Studies of the absorption and removal of propranolol in hypertensive patients during therapy. Circulation52, 313–318 (1975)
Hansson, L., Zweifler, A. J., Julius, S., Ellis, C. N.: Propranolol therapy in essential hypertension. Observations on predictability of therapeutic response. Int. J. clin. Pharmacol.10, 79–89 (1974)
Koch-Weser, J., Sellers, E. M.: Binding of drugs to serum albumin. New Engl. J. Med.294, 311–316 (1976)
Nies, A. S., Shand, D. G.: Clinical pharmacology of propranolol. Circulation52, 6–15 (1975)
Prichard, B. N. C., Gillam, P. M. S.: Treatment of hypertension with propranolol Brit. med. J.1969 I, 7–16
Shand, D. G., Nuckolls, E. M., Oates, J. A.: Plasma propranolol levels in adults with observations in four children. Clin. Pharmacol. Ther.11, 112–120 (1970)
Shand, D. G.: Individualization of propranolol therapy. Med. Clin. North. Amer.58, 1063–1069 (1974)
Shand, D. G.: Propranolol. New Engl. J. med.293, 280–285 (1975)
Stokes, G. S., Weber, M. A., Thornell, J. R.: Betablockers and plasma renin activity in hypertension. Brit. med. J.1971 I, 60–62
Wallach, L., Nyarai, I., Dawson, K. G.: Stimulated renin: A screening test for hypertension. Ann. int. Med.82, 27–34 (1975)
Zacharias, F. J., Cowen, K. J., Vickers, B. G.: Propranolol in hypertension: a study of long-term therapy 1964–1970. Amer. Heart J.83, 755–761 (1972)
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Lehtonen, A., Kanto, J. & Kleimola, T. Plasma concentrations of propranolol in patients with essential hypertension. Eur J Clin Pharmacol 11, 155–157 (1977). https://doi.org/10.1007/BF00606403
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DOI: https://doi.org/10.1007/BF00606403