Summary
The binding of semi-synthetic (16α-gitoxin and its 16-acetate) and naturally occurring cardioactive glycosides (digitoxin, ouabain) to human serum albumin was studied using equilibrium dialysis, ultracentrifugation and gel filtration. 16α-gitoxin was 75% bound and its 16-acetate 95%. The percentage binding of digitoxin and ouabain was in good agreement with values reported in literature.
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Richter, M., Haustein, K.O. Binding of 16α-gitoxin and its 16-acetate to human serum albumin. Eur J Clin Pharmacol 11, 459–461 (1977). https://doi.org/10.1007/BF00562939
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DOI: https://doi.org/10.1007/BF00562939