Summary
Studies were performed in nine male patients with moderate hypertension. Treatment with metoprolol, 50–150 mg three times daily for 4–17 weeks, had no effect on the plasma level of glycerol, free fatty acids, triglycerides or glucose under basal conditions, neither in the supine nor in the upright position. Submaximal work, performed postprandially, increased plasma glycerol before medication but not during metoprolol, in spite of a marked increase in plasma noradrenaline. The work load employed caused no change in free fatty acids, triglycerides or glucose, neither before medication nor during metoprolol.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Havel, R. J., Naimark, A., Borchgrevink, C. F.: Turnover rate and oxidation of free fatty acids of blood plasma in man during exercise: Studies during continuous infusion of palmitate-1-C14. J. clin. Invest.42, 1054–1063 (1963)
Hamlin, J. T., Hickler, R. B., Hoskins, R. G.: Free fatty acid mobilization by neuroadrenergic stimulation in man. J. clin. Invest.39, 606–609 (1960)
Björntorp, P.: Exercise in the treatment of obesity. Clinics Endocrinol. Metabol.52, 431–453 (1976)
Euler, U. S. von: Sympatho-adrenal activity and physical exercise. In: Biochemistry of Exercise (eds: Poortmans and Karger) pp 170–235. Basel: Karger 1968
Himms-Hagen, J.: Sympathetic regulation of metabolism. Pharmacol. Rev.19, 367–461 (1967)
Åblad, B., Börjesson, I., Carlsson, E., Johnsson, G.: Effects of metoprolol and propranolol on some metabolic responses to catecholamines in the anaesthetized dog. Acta pharmacol. toxicol.36, 85–95 (1975)
Hansson, B.-G., Dymling, J.-F., Manhem, P., Hökfelt, B.: Long term treatment of moderate hypertension with the beta1-receptor blocking agent metoprolol. II. Effect of submaximal work and insulin-induced hypoglycaemia on plasma catecholamines and renin activity, blood pressure and pulse rate. Europ. J. clin. Pharmacol.11, 247–254 (1977)
Hansson, B.-G., Hökfelt, B.: Effect of beta1-receptor blockade (Metoprolol, Seloken) on blood pressure, pulse rate, plasma catecholamines, renin activity and urinary aldosterone. Acta med. scand. Suppl.602, 94–96 (1976)
Hansson, B.-G., Dymling, J.-F., Hedeland, H., Hulthén, U. L.: Long term treatment of moderate hypertension with the beta1-receptor blocking agent metoprolol. I. Effect on maximal working capacity and on plasma catecholamines, plasma renin activity, urinary aldosterone, blood pressure and pulse rate under basal conditions. Europ. J. clin. Pharmacol.11, 239–245 (1977)
Eggstein, M., Kreuz, F. H.: Eine neue Bestimmung der Neutralfette im Blutserum und Gewebe. Klin. Wschr.44, 262–267 (1966)
Itaya, K., Ui, M.: Colorimetric determination of free fatty acids in biological fluids. J. Lipid. Res.6, 16–20 (1965)
Marks, V.: An improved glucose-oxidase method for determining blood, c. s. f. and urine glucose levels. Clin. chim. Acta4, 395–400 (1959)
Engelman, K., Portnoy, B.: A sensitive double-isotope derivative assay for norepinephrine and epinephrine. Circulat. Res.26, 53–57 (1970)
Muir, G. G., Chamberlain, D. A., Pedoe, T.: Effects of beta-sympathetic blockade on non-esterified-fatty-acid and carbohydrate metabolism at rest and during exercise. Lancet1964/II, 930–932
Kupiecki, F. P.: Pharmacological control of free fatty acids. Progr. Biochem. Pharmacol.6, 274–316 (1971)
Fain, J. N.: Biochemical aspects of drug and hormone action on adipose tissue. Pharmacol. Rev.25, 67–118 (1973)
Pinter, E. J., Pattee, C. J.: Effect of beta-adrenergic blockade on resting and stimulated fat mobilisation. J. clin. Endocrinol. Metab.27, 1441–1450 (1967)
Arner, P., Östman, J.: Changes in the adrenergic control and the rate of lipolysis of isolated human adipose tissue during fasting and after re-feeding. Acta med. scand.200, 273–279 (1976)
Galbo, H., Holst, J. J., Christensen, N. J., Hilsted, J.: Glucagon and plasma catecholamines during beta-receptor blockade in exercising man. J. appl. Physiol.40, 855–863 (1976)
Frisk-Holmberg, M., Östman, J.: Differential inhibition of lipolysis in human adipose tissue by adrenergic beta-receptor blocking drugs. J. Pharmacol. Exper. Therap.200, 598–605 (1977)
Thiringer, G., Svedmyr, N.: Interaction of orally administered metoprolol, practolol and propranolol with isoprenaline in asthmatics. Europ. J. clin. Pharmacol.10, 163–170 (1976)
van Herwaarden, C. L. A., Binkhorst, R. A., Fennis, J. F. M., van't Laar, A.: Effects of adrenaline during treatment with propranolol and metoprolol. Brit. med. J.1977/1, 1029
Waal-Manning, H. J.: Metabolic effects of beta-adrenoceptor blockers. Drugs11, Suppl. 1, 121–126 (1976)
Nilsson, A., Hansson, B. G., Hökfelt, B.: Beta-blockers and lipid metabolism. Brit. med. J.1977/2, 126
Deacon, S. P., Barnett, D.: Comparison of atenolol and propranolol during insulin-induced hypoglycemia. Brit. med. J.1976/2, 272–273
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nilsson, A., Hansson, B.G. & Hökfelt, B. Effect of metoprolol on blood glycerol, free fatty acids, triglycerides and glucose in relation to plasma catecholamines in hypertensive patients at rest and following submaximal work. Eur J Clin Pharmacol 13, 5–8 (1978). https://doi.org/10.1007/BF00606673
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00606673