Summary
The effects of oxprenolol and propranolol on the venoconstrictor response to noradrenaline were studied in healthy volunteers by measuring superficial dorsal hand vein diameter at a standard congesting pressure. In 8 subjects dose response curves to noradrenaline (20–1280 ng/ml) were obtained with noradrenaline alone, with noradrenaline plus propranolol 10 µg/ml, with noradrenaline plus propranolol 10 µg/ml plus oxprenolol 3 µg/ml and with noradrenaline plus propranolol 13 µg/ml according to a double blind balanced randomised design. Propranolol 10 µg/ml significantly (P<0.05) potentiated the vasoconstrictor response to noradrenaline and the addition of oxprenolol significantly (P<0.05) reversed the potentiation giving a response similar to that seen with noradrenaline alone. The higher concentration of propranolol did not produce further potentiation, the response being similar to that obtained with the lower concentration of propranolol. It is suggested that the effect of oxprenolol may be attributable to alpha blocking properties, to partial beta agonism or to its membrane stabilising properties.
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References
Astrom, A.: Influence of some local anaesthetics upon the adrenaline contraction of isolated strips of rabbit aorta. Acta Physiol. Scand.60, 30 (1963)
Barrett, A. M., Carter, J.: Comparative chronotropic activity of beta-adrenoceptive antagonists. Br. J. Pharmacol.40, 373–381 (1970)
Burks, F., Cooper, T.: Enhancement of peripheral alpha-receptor stimulation by blockade of ‘silent’ beta receptors. Circ. Res.21, 703–715 (1967)
Collier, J. G., Nachev, C., Robinson, B. F.: Effect of catecholamines and other vasoactive substances on superficial hand veins in man. Clin. Sci.43, 455–467 (1972)
Glover, W. E., Hutchinson, K. J.: The effects of a beta-receptor antagonist (propranolol) on the cardiovascular response to intravenous infusions of noradrenaline in man. J. Physiol. (Lond).177, 59P (1965)
Law, M., Rand, M. J., Story, D. F.: Effects of beta-adrenoreceptor antagonists on resting and stimulation-induced efflux of noradrenaline from rabbit ear arteries. Proc. Aust. Physiol. Pharmacol. Soc.5, 220–221 (1974)
Mazurkiewicz-Kwilecki, I. M.: Interactions of beta-adrenergic blocking agents with noradrenaline in vascular smooth muscle. Europ. J. of Pharmacol.11, 155–162 (1970)
Vaughan Williams, E. M., Papp, J. Gy.: The effects of oxprenolol on cardiac intracellular potentials in relation to its antiarrhythmic, local anaesthetic and other properties. Postgrad. Med. J. (Suppl.)46, 22–32 (1970)
White, C. de B., Udwadia, B. P.: Beta-adrenoceptor in the human dorsal hand vein, and the effects of propranolol on venous sensitivity to noradrenaline. Br. J. Clin. Pharmacol.2, 99–105 (1975)
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O'Grady, J., Oh, V. & Turner, P. Effects of propranolol and oxprenolol on the vasoconstrictor response to noradrenaline in the superficial hand vein in man. Eur J Clin Pharmacol 14, 83–85 (1978). https://doi.org/10.1007/BF00607435
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DOI: https://doi.org/10.1007/BF00607435