Summary
The effect of milk products on the gastrointestinal absorption of fluoride from sodium fluoride tablets was studied in five healthy subjects. Two different diets were tested: (1) 250 ml standardized milk (3% fat) and (2) 500 ml of milk, 3 pieces of white bread with cheese and 150 ml of yoghurt. The 100% bioavailability of sodium fluoride tablets during fasting was greatly decreased by coadministration of milk products: with Diet 1 the absolute bioavailability calculated from combined plasma and urine data was in the range 50–79% and with Diet 2 it ranged from 50–71%. It is suggested that the decreased bioavailability produced by dairy products should be taken into account when establishing fluoride dosage regimens for prophylaxis of caries.
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References
Aasenden, R., Peebles, T. C.: Effects of fluoride supplementation from birth on deciduous and permanent teeth. Arch. Oral. Biol.19, 321–326 (1974)
Carlsson, C. H., Armstrong, W. D., Singer, L.: Distribution and excretion of radiofluoride in the human. Proc. Soc. Exp. Biol. Med.104, 235–239 (1960)
Carter, R., Heerdt, M., Acciardo, S.: Fluoride kinetics after enflurane anesthesia in healthy and anephric patients and in patients with poor renal function. Clin. Pharmacol. Ther.20, 565–570 (1976)
Cremer, H. D., Büttner, W.: Absorption of fluorides. In: Fluorides and human health. WHO Monograph Series, No. 59, pp. 75–91 (Geneva 1970)
Ekstrand, J.: A micromethod for determination of fluoride in blood plasma and saliva. Calcif. Tissue Res.23, 225–228 (1977)
Ekstrand, J.: Relationship between fluoride in the drinking water and the plasma fluoride concentration in man. Caries Res.12, 123–127 (1978)
Ekstrand, J., Alván, G., Boréus, L. O., Norlin, A.: Pharmakokinetics of fluoride in man after single and multiple oral doses. Eur. J. Clin. Pharmacol.12, 311–317 (1977)
Ekstrand, J., Ehrnebo, M., Boréus, L. O.: Fluoride bioavailability after intravenous and oral administration: importance of renal clearance and urine flow. Clin. Pharmacol. Ther.23, 329–337 (1978)
Ericsson, Y.: The state of fluoride in milk and its absorption and retention when administered in milk. Investigations with radioactive fluorine. Acta Odontol. Scand.16, 51–77 (1958)
Hodge, H. C., Smith, F. A., Gedalia, I.: Excretion of fluorides. In: Fluorides and human health. WHO Monograph Series, No. 59, pp. 141–161 (Geneva 1970)
Hosking, D. J., Chamberlain, M. J.: Studies in man with18F. Clin. Sci.42, 153–161 (1972)
Jowsey, J., Riggs, L.: Effect of concurrent calcium ingestion on intestinal absorption of fluoride. Metabolism27, No. 8 (1978)
Patz, J., Henschler, D., Fickenscher, H.: Bioverfügbarkeit von Fluorid aus verschiedenen Salzen und unter dem Einfluß verschiedener Nahrungsbestandteile. Dtsch. Zahnärztl. Z.32, 482–486 (1977)
Shannon, I. L.: Biochemistry of fluoride in saliva. Caries Res.11, Suppl. 1, 206–225 (1977)
Welling, P. G.: Influence of food and diet on gastrointestinal drug absorption: A review. J. Pharmacokin. Biopharm.5, 291–334 (1977)
Whitford, G. M., Pashley, D. H. and Stringer, G. I.: Fluoride renal clearance: A pH-dependent event. Am. J. Physiol.230, 527–532 (1976)
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Ekstrand, J., Ehrnebo, M. Influence of milk products on fluoride bioavailability in man. Eur J Clin Pharmacol 16, 211–215 (1979). https://doi.org/10.1007/BF00562063
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DOI: https://doi.org/10.1007/BF00562063