Summary
The magnitude and duration of the antihypertensive effect of nifedipine were studied in 7 cases of moderate essential hypertension. In a double-blind crossover study, nifedipine 10 mg or a placebo were administered sublingually 4 times a day for 2 days, and the results were compared. Each dose of nifedipine reduced systolic and diastolic blood pressure by 14% both in the supine and upright positions. The antihypertensive action lasted for about 3 h and it was not cumulative. The reduction in blood pressure was associated with a temporary increase in heart rate. Administration of nifedipine 10 mg did not significantly raise plasma renin activity or plasma aldosterone. The drug was well tolerated and no side effects were detected.
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References
Ebner F, Dunschede HB (1976) Haemodynamics, therapeutic mechanism of action and clinical findings of Adalat use based on worldwide clinical trials. In: Jatene AD, Lichtlen PR (eds.) New therapy of ischemic heart disease. Excerpta Medica, Amsterdam pp 283–290
Aoki H, Kondo S, Mochizuki A, Yoshida T, Kato K, Kato K, Takikawa K (1978) Antihypertensive effect of cardiovascular Ca++ antagonist in hypertensive patients in the absence and presence of beta-adrenergic blockade. Am Heart J 96: 218–226
Bartorelli C, Magrini F, Moruzzi P, Olivari MT, Polese A, Fiorentini C, Guazzi M (1978) Haemodynamic effects of a calcium antagonist agent (nifedipine) in hypertension: therapeutic implications. Clin Sci Mol Med 55: 291–292
Aoki I, Yoshida T, Kato S, Tazumi K, Sato I, Takikawa K, Hotta K (1976) Hypertensive action and increased plasma renin activity by Ca++ antagonist (Nifedipine) in hypertensive patients. Jpn Heart J 17: 479–484
Corvol P, Menard J, Bertagna X (1973) Dosages radio-immunologiques de l'aldostérone et de l'activité rénine plasmatique. Ann Endocrinol (Paris) 34: 57–65
Olivari MT, Bartorelli C, Polese A, Fiorentini C, Moruzzi P, Guazzi M (1979) Treatment of hypertension with Nifedipine, a calcium antagonistic agent. Circulation 59: 1056–1062
Report of the international Adalat Panel Discussion. New experimental and clinical results. Amsterdam Oxford Excerpta Medica 1979 and Fourth International Adalat symposium Amsterdam Excerpta Medica. (In press) Excerpta Medica, Amsterdam
Guazzi M, Olivari MT, Polese A, Fiorentini C, Magrini F, Moruzzi P (1977) Nifedipine, a new antihypertensive with rapid action. Clin Pharmacol Ther 22: 528–532
Gutsche HU, Müller-Suur R, Schurek HJ (1975) Ca++ antagonist prevents feedback induced SN-GFR decrease in rat kidney. Kidney Int. 8: 477
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Thibonnier, M., Bonnet, F. & Corvol, P. Antihypertensive effect of fractionated sublingual administration of nifedipine in moderate essential hypertension. Eur J Clin Pharmacol 17, 161–164 (1980). https://doi.org/10.1007/BF00561894
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DOI: https://doi.org/10.1007/BF00561894