Summary
Sex histories and serum samples were obtained from 27 hypertensive men before and after 3 months of therapy with either 100 mg of hydrochlorothiazide or 0.25 mg of reserpine daily. Sera were analyzed for testosterone, dihydrotestosterone, estradiol, luteinizing hormone and prolactin. Both drugs effectively lowered blood pressure. The incidence of impaired sexual performance was low and insignificantly different in the two treatment groups. There were no significant changes in serum hormone concentrations as a result of drug therapy.
Similar content being viewed by others
References
Hollander W, Wilkins RW (1966) The pharmacology and clinical use of rauwolfia, hydralazine, thiazides, and aldosterone antagonists in arterial hypertension. Prog Cardiovasc Dis 8: 291–318
Bulpitt CJ, Dollery CT (1973) Side effects of hypotensive agents evaluated by a self-administered questionaire. Br Med J 3: 485–490
Veterans Administration Cooperative Study Group on Antihypertensive Agents (1962) Double-blind control study of antihypertensive agents: III. Chlorothiazide alone and in combination with other agents, preliminary results. Arch Intern Med 110: 230–236
Tuchmann-Duplessis H (1956) Influence de la reserpine sur les glandes endocrines. Presse Med 64: 2189–2192
Furuyama S, Mayes DM, Nugent CA (1970) A radioimmunoassay for plasma testosterone. Steroids 16: 415–428
McCann SM (1977) Luteinizing-hormone-releasing-hormone. N Engl J Med 296: 797–802
Sharp PJ (1975) The effect of reserpine on plasma LH concentration in intact and gonadectomized domestic fowl. Br Poult Sci 16: 79–82
Coppola JA, Leonardi RG, Lippmann W (1966) Ovulatory failure in rats after treatment with brain norepinephrine depletors. Endocrinology 78: 225–228
Turkington RW (1972) Prolactin secretion in patients treated with various drugs. Arch Intern Med 130: 349–354
Lee PA, Kelly MR, Wallin JD (1976) Increased prolactin levels during reserpine treatment of hypertensive patients. J Amer Med Assoc 235: 2316–2317
Gibb WE, Turner P, Malpas JS, White RJ (1970) Comparison of bethanidine, α-methyldopa, and reserpine in essential hypertension. Lancet 2: 275–277
Veterans Administration Cooperative Study Group on Antihypertensive Agents (1972) Effects of treatment on morbidity in hypertension: III. Influence of age, diastolic pressure, and prior cardivascular disease; further analysis of side effects. Circulation 45: 991–1004
Veterans Administration Cooperative Study Group on Antihypertensive Agents (1977) Propranolol in the treatment of essential hypertension. J Amer Med Assoc 237: 2303–2310
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Boyden, T.W., Nugent, C.A., Ogihara, T. et al. Reserpine, hydrochlorothiazide and pituitary-gonadal hormones in hypertensive patients. Eur J Clin Pharmacol 17, 329–332 (1980). https://doi.org/10.1007/BF00558444
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00558444