Summary
Prednisolone was measured in plasma, saliva and urine at various times after a single dose. Peak plasma prednisolone levels were observed about 1 h after the dose. Saliva prednisolone levels were measurable for at least 3 h after dosing but showed no consistent relationship to either total or free plasma prednisolone concentrations. Unchanged prednisolone in amounts up to 14% of the dose administered was found in the 24 h urine and most of it was excreted in the first 5 h.
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Chakraborty, J., Hayes, M., English, J. et al. Prednisolone concentrations in plasma, saliva and urine. Eur J Clin Pharmacol 19, 79–81 (1981). https://doi.org/10.1007/BF00558389
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DOI: https://doi.org/10.1007/BF00558389