Summary
Nalorphine 5 mg im caused a significant increase in serum PRL in 8 healthy volunteers. Pretreatment with bromocriptine 5 mg inhibited the nalorphine-induced release of PRL, whereas sulpiride administration enhanced it.
References
Barreca T, Marabini A, Magnani G, Sannia A, Rolandi E (1980) Naloxone does not affect pituitary secretion in healthy man. IRCS Med Sci 8: 908
Blankstein J, Beyes F, Winter J, Faiman C (1979) Failure of naloxone to alter growth hormone and prolactin levels in acromegalic and hyperprolactinaemic patients. Clin Endocrinol 11: 475–479
Bruni JF, Van Vugt D, Marshall S, Meites J (1977) Effects of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle stimulating hormone, thyroid stimulating hormone and growth hormone. Life Sci 21: 461–466
Del Pozo E, Lancranjan I (1978) Clinica use of drugs modifying the release of anterior pituitary hormones. In: Ganong WF, Martini L (eds) Frontiers in neuroendocrinology. Raven Press, New York, pp 207–247
Edwards AL (eds) (1967) Statistical Methods. Holt, Rinehart and Winston, New York, pp 353–355
Gold MS, Donabedian RK, Dillard M, Slobets FW, Riordan CE, Kleber HD (1977) Antipsychotic effect of opiate agonists. Lancet 2: 385–386
Lien EL, Morrison A, Dvonch WM (1979) The effects of partial opiate agonists on plasma prolactin and growth hormone levels in the rat. Life Sci 25: 1709–1716
MacLeod RM (1976) Regulation of prolactin secretion. In: Martini L, Ganong WF (eds) Frontiers in neuroendocrinology. Raven Pess, New York, pp 169–194
Martin WR (1981) Multiple opioid receptors. Life Sci 28: 1547–1554
Morley JE (1981) Rhe endocrinology of the opiate and opioid peptides. Metabolism 30: 195–209
Morley JE, Barnetsky NG, Wingert TD, Calson HE, Hershman JM, Melmed S, Levin SR, Jamison KR, Weitzman R, Chang RJ, Warner AA (1980) Endocrine effects of naloxone-induced opiate receptor blockade. J Clin Endocrinol Metab 50: 251–257
Quigley ME, Sheehan KL, Casper RLF, Yen SSG (1980) Evidence for an increased opioid inhibition of luteinizing hormone secretion in hyperprolactinemic patients with pituitary microadenoma. J Clin Endocrinol Metab 50: 427–430
Rolandi E, Barreca T (1978) Effects of two analgesic opiates (methadone and pentazocine) on the serum prolactin levels in breast cancer. Acta Endocrinol 88: 452–454
Rolandi E, Magnani G, Sannia A, Barreca T (1980) Prolactin changes induced by a partial opiate antagonist, nalorphine. IRCS Med Sci 8: 570
Sinha YN, Selby FW, Lewis UJ, Vanderlaan WP (1973) A homologous radioimmunoassay for human prolactin. J Clin Endocrinol Metab 36: 509–516
Tolis G, Hickey J, Guyda H (1975) Effect of morphine on serum GH, PRL, TSH and cortisol in man. J Clin Endocrinol Metab 41: 797–800
Tolis G, Dent R, Guyda H (1978) Opiates, prolactin, and the dopamine receptor. J Clin Endocrinol Metab 47: 200–203
Van Vugt DA, Bruni JF, Meites J (1978) Naloxone inhibition of stress-induced increase in prolactin secretion. Life Sci 22: 85–90
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Barreca, T., Magnani, G., Sannia, A. et al. Changes in nalorphine-induced hyperprolactinaemia after bromocriptine or sulpiride administration. Eur J Clin Pharmacol 22, 375–376 (1982). https://doi.org/10.1007/BF00548408
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00548408