Summary
Repeated doses of a new β-adrenoceptor blocking agent, befunolol, were administered orally to adult male volunteers for a cross-over comparison with propranolol. The β-adrenoceptor blocking activity of befunolol was greater than that of propranolol when assessed by the percentage reduction in exercise-induced tachycardia. The elimination half-life of drug was significantly prolonged on repeated administration of propranolol, but not of befunolol. The percentage reduction in exercise-induced tachycardia was highly correlated with the log plasma level of each drug. Both drugs produced a significant reduction in pre-exercise systolic and diastolic blood pressure, and significant attenuation of exercise-induced rise in systolic blood pressure.
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Ebihara, A., Tawara, K., Oka, T. et al. Clinical pharmacology of a new β-adrenoceptor blocking drug, befunolol. Eur J Clin Pharmacol 23, 189–195 (1982). https://doi.org/10.1007/BF00547552
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DOI: https://doi.org/10.1007/BF00547552