Summary
The systemic availability of acetylsalicylic acid (ASA) after oral ingestion of 1 g in an effervescent formulation was 16.3±2.0% and 16.9±3.2% of the ingested dose in normal women and men, respectively. The average plasma half-life of ASA in each sex was also identical at 18.5±1.4 and 18.1±1.2 min, respectively. The inhibitory effect of ASA on collagen-induced platelet aggregation in vitro on blood from both sexes was studied. The IC50 was 23.9±2.9 µg/ml in females and 22.5±2.7 µg/ml in males, which did not differ significantly. The inhibition by salicylic acid (SA) of the antiaggregatory effect of ASA was similar in both sexes with increases in IC50 to 33.5±5.1 µg/ml in females (p<0.02) and to 29.5±3.8 µg/ml in males (p<0.05). It is concluded that the observed sex-difference in the antithrombotic effect of ASA cannot be explained neither by differences between females and males in the pharmacokinetic properties of ASA after oral ingestion, nor by differences in the in vitro effect of ASA on the platelet aggregation induced by collagen.
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References
Canadian Cooperative Study Group (1978) A randomized trial of aspirin and sulfinpyrazone in threatened stroke. N Engl J Med 299: 53–59
Harris WH, Salzman EW, Athanasoulis CA, Waltman AC, DeSanctis RW (1977) Aspirin prophylaxis of venous thromboembolism after total hip replacement. N Engl J Med 297: 1246–1249
Linos A, Worthington JW, O'Fallon W, Fuster V, Whisnant JP, Kurland LT (1978) Effect of aspirin on prevention of coronary and cerebrovascular disease in patients with rheumatoid arthritis. Mayo Clin Proc 53: 581–586
Gilles MA, Skyring A (1969) Gastric and duodenal ulcer. The association between aspirin ingestion, smoking and family history of ulcer. Med J Aust 2: 280–285
Menguy R, Desbaillets L, Masters YF, Okabe S (1972) Evidence for a sexliked difference in aspirin metabolism. Nature 239: 102–103
Rowland M, Riegelman S (1968) Pharmacokinetics of acetylsalicylic acid and salicylic acid after intravenous administration in man. J Pharm Sci 57: 1313–1319
Petersen T, Husted SE, Pedersen AK, Geday E (1982) Systemic availability of acetylsalicylic acid in normal human subjects after oral ingestion of three different formulations. Acta Pharmacol Toxicol 51: 285–291
Koch PA, Schultz CA, Wills RJ, Hallquist SL, Welling PG (1978) Influence of food and fluid ingestion on aspirin biovailability. J Pharm Sci 67: 1533–1535
Graham GG, Champion GD, Day RO, Paull PD (1977) Patterns of plasma concentrations and urinary excretion of salicylate in rheumatoid arthritis. Clin Pharmacol Ther 22: 410–420
Johnson M, Ramey E, Ramwell PW (1975) Sex and age differences in human platelet aggregation. Nature 253: 355–357
Vargaftig BB (1978) The inhibition of cyclo-oxygenase of rabbit platelets by aspirin is prevented by salicylic acid and by phenanthrolines. Eur J Clin Pharmacol 50: 231–241
Brantmark B, Hedner U, Melander A (1981) ASA — tro och vetande — acetylsalicylsyra i nytt ljus. Läkartidningen 78: 2351–2352
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Husted, S.E., Pedersen, A.K., Petersen, T. et al. Systemic availability of acetylsalicylic acid in normal men and women and its effect on in vitro platelet aggregability. Eur J Clin Pharmacol 24, 679–682 (1983). https://doi.org/10.1007/BF00542222
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DOI: https://doi.org/10.1007/BF00542222