Summary
The disposition of fluphenazine was investigated in six healthy volunteers following oral administration (5 mg). Using a sensitive and specific GC-MS procedure plasma fluphenazine concentrations were measured up until 32 h after drug administration. Peak plasma concentrations varied widely (range: 0.26–1.06 ng/ml) and were observed at 2.8±0.5 h following fluphenazine administration. The apparent terminal elimination half-life of fluphenazine was 33.1±8.1 h. The area under the plasma concentration-time curve differed widely between subjects (range: 7.1–28.6 ng/ml h) suggesting large interindividual differences in the extent of fluphenazine presystemic elimination.
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Midha, K.K., McKay, G., Edom, R. et al. Kinetics of oral fluphenazine disposition in humans by GC-MS. Eur J Clin Pharmacol 25, 709–711 (1983). https://doi.org/10.1007/BF00542363
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DOI: https://doi.org/10.1007/BF00542363