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Comparison of the short-term effects of the loop diuretic piretanide and furosemide in patients with renal insufficiency

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Summary

The natriuretic effect of the new loop diuretic piretanide was investigated in patients with severe renal insufficiency and was compared with that of furosemide. In the first study 4 hospitalized patients (serum creatinine 407 to 1220 µmol/l) were examined after administration of piretanide (12, 24, 48 and 96 mg to two patients, and 24, 48, 96 and 192 mg to 2 other subjects, given every third day). In the second study 6 hospitalized patients (serum creatinine 194 to 698 µmol/l) were studied after receiving orally 2 different doses of piretanide and 2 different doses of furosemide orally, given every fourth day. The mean natriuretic effect of 48 mg and 96 mg piretanide was 250 and 340% of the control value for the entire group, and 311 to 480% in the subgroup of patients with serum creatinine below 530 µmol/l. For a given dose the natriuresis was inversely correlated with renal function, and at a given serum creatinine level the natriuretic response was dose-dependent. The drug had less effect on water and potassium diuresis than on natriuresis. No significant difference in natriuretic effect was found on comparison with furosemide given in the ratio furosemide: piretanide 3.33:1. The pharmacokinetic data showed a direct correlation between the dose and the mean plasma concentration and also between urinary recovery of the drug and the measured natriuretic response.

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References

  1. Marone C, Reubi FC (1980) Effects of a new diuretic (piretanide) compared with furosemide on renal diluting and concentrating mechanisms in patients with the nephrotic syndrome. Eur J Clin Pharmacol 17: 165–171

    Google Scholar 

  2. Teredesai P, Puschett JB (1979) Acute effects of piretanide in normal subjects. Clin Pharmacol Ther 25: 331–339

    Google Scholar 

  3. Winaver J, Sylk DB, Teredesai PR, Robertson JS, Puschett JB (1980) Dissociative effects of piretanide on proximal tubular PO4 and HCO3 transport. Am J Physiol 238: F60–F68

    Google Scholar 

  4. Lawrence JR, Ansari AF, Elliot HL, Summer DJ, Brunton GF, Whiting B, Whitesmith R (1978) Kinetic and dynamic comparison of piretanide and furosemide. Clin Pharmacol Ther 23: 559–565

    Google Scholar 

  5. Merkel W, Bornmann D, Mania D, Muschaweck R, Hropot M (1978) Piretanide (HOE 118) a new high ceiling salidiuretic. Eur J Med Chem-Chimica Therap 11: 399–406

    Google Scholar 

  6. Roberts CJC, Homeida M, Roberts F, Bogie W (1978) Effects of piretanide, bumetanide and frusemide on electrolyte and urate excretion in normal subjects. Br J Clin Pharmacol 6: 129–133

    Google Scholar 

  7. Hadjassa A, Pozet N, Labeeuw M, Pellet M, Traeger J (1981) Acute effect of a high dose (48 mg) of piretanide in advanced renal insufficiency. Br J Clin Pharmacol 1: 63–68

    Google Scholar 

  8. Pozet N, Hadjassa A, Pellet M, Traeger J (1980) Activity of a new high efficiency diuretic in man: piretanide (HOE 118). Br J Clin Pharmacol 9: 577–583

    Google Scholar 

  9. Sjöström P (1981) The diuretic effect of piretanide in uremic patients. Abstracts VIII Int Cong Nephrology, Publ. University Studio, Thessaloniki, Greece, 199

    Google Scholar 

  10. Arroyo V, Bosch J, Casamitjana R, Cabrera J, Rivera F, Rodes J (1980) Use of piretanide, a new loop diuretic, in cirrhosis with ascites. Gut 21: 855–859

    Google Scholar 

  11. Homeida M, Roberts CJC, Dombey SL (1979) A single dose comparison of piretanide and bumetanide in congestive cardiac failure. Br J Clin Pharmacol 8: 173–178

    Google Scholar 

  12. Kaojarern S, Day B, Brater DC (1982) The time course of delivery of furosemide into urine: An independent determinant of overall response. Kidney Int 22: 69–74

    Google Scholar 

  13. Reubi FC (1966) Clinical use of furosemide. Ann N.Y. Acad Sci 139: 433–442

    Google Scholar 

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Marone, C., Reubi, F.C. & Lahn, W. Comparison of the short-term effects of the loop diuretic piretanide and furosemide in patients with renal insufficiency. Eur J Clin Pharmacol 26, 413–418 (1984). https://doi.org/10.1007/BF00542133

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  • DOI: https://doi.org/10.1007/BF00542133

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