Summary
The pharmacokinetics of omeprazole were studied in a group of healthy male subjects after single and repeated oral doses of 30 and 60 mg. Absorption of omeprazole from its enteric-coated formulation was unpredictable. There was a highly significant increase in the area under the plasma concentration time curve (AUC) after repeated dosing. Omeprazole increases its own relative availability following repeated dosing. This may be due to inhibition of gastric acid secretion by omeprazole which is an acid-labile compound.
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References
Fellenius E, Berglindh T, Sachs G, Olbe L, Elander B, Sjostrand S-E, Wallmark B (1981) Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase. Nature 290: 159–161
Howden CW, Forrest JAH, Reid JL (1984) Effects of single and repeated doses of omeprazole on gastric acid and pepsin secretion in man. Gut (in press)
Lind T, Cederberg C, Ekenved G, Haglund U, Olbe L (1983) Effect of omeprazole — a gastric proton pump inhibitor — on pentagastrin stimulated acid secretion in man. Gut 24: 270–276
Walt RP, Gomes M de FA, Wood EC, Logan LH, Pounder RE (1983) Effect of daily oral omeprazole on 24 hour intragastric acidity. Br Med J 287: 12–14
Prichard PJ, Mihaly GW, Jones DB, Yeomans ND, Louis WJ, Smallwood RA (1984) Omeprazole — its oral pharmacokinetics. Br J Clin Pharmacol 17: 612 p (abstract)
Gustavson S, Loof L, Adami H-O, Nyberg A, Nyren O (1983) Rapid healing of duodenal ulcers with omeprazole: double-blind dose-comparative trial. Lancet 2: 124–125
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Howden, C.W., Meredith, P.A., Forrest, J.A.H. et al. Oral pharmacokinetics of omeprazole. Eur J Clin Pharmacol 26, 641–643 (1984). https://doi.org/10.1007/BF00543502
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DOI: https://doi.org/10.1007/BF00543502