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Long-term low dose ticlopidine treatment in rheumatoid arthritis: Effects on serum sulphydryl levels, technetium index, erythrocyte sedimentation rate, and clinical disease activity

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Summary

In 22 patients with rheumatoid arthritis oral ticlopidine 250 mg/day for 18 months induced clinical improvement, confirmed by a significant decrease in the counts of involved joint. A significant decrease was observed in the technetium index (Tc-index) and the erythrocyte sedimentation rate (ESR), and a significant increase occurred in the serum sulphydryl (SH) levels. The long-term changes in serum SH and Tc-index produced by ticlopidine may represent a specific antirheumatic activity of this platelet-inhibiting drug.

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  1. 2nd Department of Medicine, Fatebenefratelli Hospital, Milano, Italy

    M. G. Grimaldi

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  1. M. G. Grimaldi
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Grimaldi, M.G. Long-term low dose ticlopidine treatment in rheumatoid arthritis: Effects on serum sulphydryl levels, technetium index, erythrocyte sedimentation rate, and clinical disease activity. Eur J Clin Pharmacol 29, 165–168 (1985). https://doi.org/10.1007/BF00547416

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  • DOI: https://doi.org/10.1007/BF00547416

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