Summary
A possible interaction of penbutolol and cimetidine was investigated in healthy volunteers treated orally for 7 days.
The plasma levels of unmetabolised penbutolol showed a slight but non-significant increase. The biphasic elimination kinetics of penbutolol (half-lives 0.8 and 17 h) was not affected by coadministration of cimetidine. Plasma levels of penbutolol were not significantly altered by chronic treatment with cimetidine, whereas the levels of 4-hydroxypenbutolol and 4-hydroxypenbutolol glucuronide were significantly reduced.
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Spahn, H., Kirch, W., Hajdu, P. et al. Penbutolol pharmacokinetics: the influence of concomitant administration of cimetidine. Eur J Clin Pharmacol 29, 555–560 (1986). https://doi.org/10.1007/BF00635892
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DOI: https://doi.org/10.1007/BF00635892