Summary
1. The effect of dopamine on renal blood flow as measured directly by an indicator dilution technique has been studied in eleven hypertensive patients. — 2. Dopamine (1 and 2 µg/kg body wt/min) caused a mean increase of 77.1% and 121.6% respectively in renal blood flow. This was four to five times greater than the corresponding change produced in cardiac output (+16.8% and +37% respectively over control values). — Neither propranolol (2 studies) nor phentolamine (1 study) blocked these changes in renal blood flow. — 4. Dopamine 2 µg/kg body wt/min caused a mean increase in sodium excretion from 0.269±0.246 mequiv/min to 0.942±0.429 mequiv/min in 4 hypertensive subjects. There was also an increase in glomerular filtration rate, measured by inulin clearance, from 95.2±13.8 ml/min to 124.7±13.4 ml/min and in effective renal blood flow measured by PAH clearance from 490.2±170.8ml/min to 673.0±256.2 ml/min.
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References
Bratton, A. C., Marshall, E. K.: A new coupling component for sulphanilamide determination J. biol. Chem.128, 537–550 (1939).
Davis, B. B., Walter, M. J., Murdaugh, H. V.: The mechanism of the increase in sodium excretion following dopamine infusion. Proc. Soc. Exp. Biol. Med.129, 210–213 (1968).
Dollery, C. T., Goldberg, L. I., Pentecost, B. L.: Effects of intrarenal infusions of bradykinin and acetylcholine on renal blood flow in man. Clin. Sci.29, 433–441 (1965).
Finlay, G. D., Whitsett, T. L., Cucinell, E. A., Goldberg, L. I.: Cardiac and renal effects of L Dopa in patients with Parkinson's disease and congestive heart failure. Circulation, Suppl. III, 109 (1970).
Goldberg, L. I., McDonald, R. H., Zimmerman, A. M.: Sodium diuresis produced by dopamine in patients with congestive heart failure. New Engl. J. Med.269, 1060–1064 (1963).
Keith, N. M., Wagener, H. P., Barker, N. W.: Some different types of essential hypertension: their course and prognosis. Amer. J. Med. Sci.197, 332–343 (1939).
McDonald, R. H., Goldberg, L. I.: Analysis of the cardiovascular effects of dopamine in the dog. J. Pharmacol. Exp. Ther.140, 60–66 (1963).
McDonald, R. H., Goldberg, L. I., Mc Nay, J. L., Tuttle, E. P.: Effect of dopamine in man: augmentation of sodium excretion, glomerular filtration rate and renal plasma flow. J. clin. Invest.43, 1116–1124 (1964).
McNay, J. L., Goldberg, L. I.: Haemodynamic effects of dopamine in the dog before and after alpha adrenergic blockade. Circulat. Res. Suppl. I.18 and19, 110–119 (1966).
Pentecost, B. L., Irving, D. W., Shillingford, J. P.: The effects of posture on the blood flow in the inferior vena cava. Clin. Sci.24, 149–158 (1963).
Shillingford, J. P., Bruce, T., Gabe, I.: The measurement of segmental venous flow by an indicator dilution method. Brit. Heart J.24, 157–165 (1962).
Smith, H. W.: The kidney; structure and function in health and disease, p. 164. New York: Oxford University Press 1951.
Webster, M. E., Gillmore, J. P.: Influence of kallidin-10 on renal function. Amer. J. Physiol.206, 714–718 (1964).
Young, M. K., Raisz, L. G.: An anthrone procedure for determination of inulin in biological fluids. Proc. Soc. exp. Biol. Med.80, 771–774 (1952).
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Breckenridge, A., Orme, M. & Dollery, C.T. The effect of dopamine on renal blood flow in man. Eur J Clin Pharmacol 3, 131–136 (1971). https://doi.org/10.1007/BF00572452
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DOI: https://doi.org/10.1007/BF00572452