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Methotrexate in erythrocytes of patients with psoriasis

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Summary

Methotrexate (MTX) concentrations in erythrocytes in 32 psoriatics treated weekly with MTX p.o. or i.m. have been studied. When treatment had been constant for at least 5 weeks, there was only small variation in erythrocyte MTX (ery-MTX) in the week between two courses of treatment. The ery-MTX was correlated with the weekly dose of MTX. For patients treated with MTX i.m.r=0.87, and in patients given divided oral dosesr was 0.68. There was no difference in ery-MTX between the two routes of administration. No correlation was observed between ery-MTX and the total MTX dose or the length of treatment. During constant MTX administration small variations in ery-MTX were observed. Small changes in the weekly dose of MTX resulted in marked changes in ery-MTX in 4 of the 5 patients studied.

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Authors and Affiliations

  1. Departments of Clinical Chemistry and Pediatrics, Aarhus Kommunehospital, Aarhus, Denmark

    H. Schrøder & E. K. Foged

  2. Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark

    E. K. Foged

Authors
  1. H. Schrøder
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  2. E. K. Foged
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Schrøder, H., Foged, E.K. Methotrexate in erythrocytes of patients with psoriasis. Eur J Clin Pharmacol 30, 453–456 (1986). https://doi.org/10.1007/BF00607959

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  • DOI: https://doi.org/10.1007/BF00607959

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