Summary
We have tested the usefulness of the critical flicker fusion threshold-test (CFF), Maddox wing readings (MW), and visual analoque scale scores (VAS) in a double-blind, random-order study designed to evaluate the clinical effects of two different kinds of opiates, buprenorphine and fentanyl in comparison with those of placebo. The results were compared with the so-called postanaesthetic recovery score (PARS).
In 7 healthy volunteers MW and VAS differentiated the effects of buprenorphine 7.5 µg/kg i.v. from those of fentanyl 2.5 µg/kg i.v. and placebo. CFF was very insensitive in this respect and PARS completely useless.
Our results show that, in addition to the known usefulness of VAS, MW is also able to differentiate the effects of these opiates.
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References
Aldrete JA, Kroulik D (1970) A postanaesthetic recovery score. Anaesth Analg 49: 924–934
Bond A, Lader M (1974) The use of analoque scales in rating subjective feelings. Br J Med Psychol 47: 211–218
Cohen L, Holliday M (1982) Statistics for social scientists. Harper and Row Ltd, London
De Castro JE, Andrieu S, Boogaerts J (1982) Buprenorphine. A review of its pharmacological properties and therapeutic uses. ARS MEDICI. Int J Pract Ther 1: 85–86
Grove-White IG, Kelman GR (1971) Critical flicker frequency after small doses of methodexitone, diazepam and sodium-4-hydroxybutyrate. Br J Anaesth 43: 110–112
Hannington-Kiff JG (1970a). Residual post-operative paralysis. Proc R Soc Med 63: 73–76
Hannington-Kiff JG (1970b) Measurement of recovery from outpatient general anaesthesia with a simple ocular test. Br Med J 3: 132–135
Heel RC, Brogden RN, Speight TM, Avery GS (1979) Buprenorphine. A review of its pharmacological properties and therapeutic efficacy. Drugs 17: 81–110
Hindmarch I (1980) Psychomotor function and psychoactive drugs. Br J Clin Pharmacol 10: 189–209
Huskisson EC (1974) Measurement of pain. Lancet 2: 1127–1131
Kay B, Venkataramam P (1983) Recovery after fentanyl and alfentanil in anaesthesia for minor surgery. Br J Anaesth 55: 169 S-171 S
Manner T, Kanto J, Salonen M (1986) Simple devices in determining residual effects of the analgetic component of combination anaesthesia. Br J Anaesth (in press)
Mather LE (1983) Clinical pharmacokinetics of fentanyl and its newer derivates. Clin Pharmacokinetics 8: 422–446
Maxwell C (1978) Sensivity and accuracy of the visual analoque scale: A psycho-physical classroom experiment. Br J Clin Pharmacol 6: 15–24
Revill SI, Robinson JO, Rosen M, Hogg MIJ (1976) The reliability of a linear analoque scale for evaluating pain. Anaesthesia 31: 1191–1198
Sear JW, Cartwright DP, Alexander JI (1979) Buprenorphine for postoperative analgesia. Br J Anaesth 51: 71
Simonson E, Brozek J (1952) Flicker fusion frequency: Background and applications. Physiol Rev 32: 349–378
Smith JM, Misiak H (1976) Critical flicker fusion frequency (CFF) and psychotropic drugs in normal human subjects — A review. Psychopharmacology 47: 175–182
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Manner, T., Kanto, J. & Salonen, M. Simple devices in differentiating the effects of buprenorphine and fentanyl in healthy volunteers. Eur J Clin Pharmacol 31, 673–676 (1987). https://doi.org/10.1007/BF00541294
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DOI: https://doi.org/10.1007/BF00541294