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Acute renal effects of oral felodipine in normal man

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Summary

The acute renal effects of a single oral dose of felodipine 0.15 mg/kg were studied in 8 healthy males. Thirty minutes after administration the mean plasma concentration was 25.7 nmol/l. There was a significant reduction in diastolic blood pressure (24%) and a concomitant rise in heart rate (38%), leaving the systolic pressure unchanged. Glomerular filtration rate (GFR) and renal plasma flow (RPF) were measured by the constant infusion technique using the clearance of125I-iothalamate and131I-hippuran respectively. GFR was unchanged and the filtration fraction (FF) was reduced, whilst there was a decrease in renal vascular resistance (RVR). The glomerular filter characteristics were unchanged, as estimated by the unchanged excretion rate of albumin. There was a significant rise in the clearance of sodium (176%) but only a small and insignificant increase in urine volume. Clearance of potassium was decreased. An increase in the clearance of uric acid and a rise in the beta-2-microglobulin excretion rate were found, both suggesting a proximal tubular effect of felodipine. The excretion rate of calcium was increased.

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  1. Second University Clinic of Internal Medicine, Aarhus Kommunehospital, Aarhus C, Denmark

    A. Schmitz

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  1. A. Schmitz
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Schmitz, A. Acute renal effects of oral felodipine in normal man. Eur J Clin Pharmacol 32, 17–22 (1987). https://doi.org/10.1007/BF00609952

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  • DOI: https://doi.org/10.1007/BF00609952

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