Summary
The concentration-time curves of azapropazone in synovial fluid and tissues have been studied in arthritic patients after an i.v. bolus (600 mg) and under steady-state conditions. Synovial fluid and tissue samples were taken intraoperatively 0.45–60 h after administration. The azapropazone concentrations in synovial fluid, synovial tissue and plasma were correlated. The levels in synovial fluid were usually lower than corresponding plasma levels. Under steady-state conditions azapropazone did not accumulate in synovial tissues.
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Spahn, H., Thabe, K., Mutschler, E. et al. Concentration of azapropazone in synovial tissues and fluid. Eur J Clin Pharmacol 32, 303–307 (1987). https://doi.org/10.1007/BF00607579
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DOI: https://doi.org/10.1007/BF00607579